Fig. 5

Functional network connectivity in dorsal CA1. A) Example of overlaid Ca²⁺ signals (∆F/F) from pairs of cells (cell 1 in red lines, cell 2 in black lines) that were co-active (top), or not (bottom). B) Example of correlations between pairs of cells that were significantly correlated (top) or not (bottom). Dark dots represent individual Ca²⁺ signals paired by time, and blue line represents the line of best fit. C) Example of a functional network of CA1 cells generated after thresholding for positive correlations (P < 0.001). Edges represent correlation coefficient values, and node size and color indicate closeness centrality. D) Degree centrality values, indicating synchronously active cells, expressed as a percentage of baseline values from the habituation session. E) Clustering coefficient values, indicating the proportion of mutually interconnected cells, expressed as a percentage of baseline values from the habituation session. F) Closeness centrality values, indicating the accessibility of the nodes in the network, expressed as a percentage of baseline values from the habituation session. D-F) S1 (novel item-place exposure), S2 (re-exposure), S3 (novel item configuration). Points and shaded ribbons represent mean ± 95% confidence intervals. The control group is colored in blue, and the β-AR antagonist group is colored in red. Asterisks indicate statistical significance at *p < 0.05, **p < 0.01, ***p < 0.001. N = 8 per group.