Anesthetics are important agents for mitigating painful procedures. An animal under a general anesthesia benefits from its use, but as physiological parameters can differ between conscious and unconscious subjects, such agents can complicate the interpretations of experimental results. When choosing an anesthetic for their study animals, researchers need to be aware of how a given agent may influence their animals and in turn, the outcomes of the study.

In a new Research Article, Yan-Yuen Poon and colleagues from the Chang Gung Memorial Hospital in Taiwan deploy a variety of measures – including telemetry, blood flow analyses, MRI, and echocardiography – in awake and anesthetized animals to revisit the effects of an anesthetic long thought to cause cardiovascular depression in mice: isoflurane

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