Companion animals such as dogs and cats develop spontaneous cancers that closely recapitulate their human counterparts with respect to clinical presentation, histological features, molecular profiles, and response to therapy. Understanding companion animal cancers could therefore help to inform treatments for human patients.

Both dogs and humans develop diffuse large B-cell lymphoma (DLBCL), an aggressive type of non-Hodgkin lymphoma that arises from B-cells. In a new article this month, Diana Giannuzzi and colleagues performed an integrated analysis of exome and RNA sequencing data in a cohort of dogs with DLBCL to determine the genomic landscape of this tumor. The study comprehensively identified several genetic drivers of DLBCL, providing potential therapeutic targets for both canine and human DLBCL.

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