Fig. 2: Performance of breeding models, in the case of an average litter size of 7 and a mouse fertility of 70%.
a, Bottom: minimal number of breedings (y axis) needed to obtain the desired number of offspring (x axis) with 90% confidence, as calculated by three methods: the naive expectation due to Mendelian frequency (set to 100%; Supplementary Methods), the gold-standard textbook model suggested by Festing, and our method, denoted as Poisson. Top: relative surplus of breeding (in %) obtained by the textbook method (Festing), measured against our method (bottom). b, Minimal number of breedings needed to obtain a certain number of offspring (x axis) with a defined probability of success (y axis) using the Poisson method. c, Minimal number of breeding (contour lines) required in a setup where groups with two different genotypes need to be produced by the same breeding (90% confidence). The required numbers of animals from the two genotypes, that appear at a frequency of 25% each, are denoted on the x and y axis. d, Minimal number of breeding required to obtain offspring of specific sexes with 90% confidence, given that both female (F) and male (M) pups are born with equal probability. Shown are three scenarios: required X offspring need to be of the same sex (only X males or X females (purple)); X offspring can be of any sex (brown); required X offspring need to be balanced cohorts of each sex (that is, X/2 male and X/2 female pups, green).
