Dr. T. Guaio, an established faculty member at Great Eastern University (GEU), studies animal models of hemophilia with the goal of finding effective gene therapies. Recently, Guaio completed the statistical analyses of 6 months’ worth of data from his rabbit research. Much to his dismay, the results were inconclusive and rather chaotic. This was surprising, and troubling, because prior results were clear and statistically significant with a low p-value. Consequently, Guaio consulted with his colleague Dr. Altra Ipotesi.
During the conversation, Ipotesi asked Guaio about the specific animals used in the experiments; e.g., how they were housed, from where they were obtained, and were there any other health issues. Guaio responded that he bred the rabbits in-house – some rabbits were purchased from a vendor and some were obtained from another GEU faculty member, Dr. Stesso Virale. As the conversation progressed, Guaio disclosed that the animals he obtained from Virale were the progeny of transgenic (TG) rabbits, a model created by Virale for studying anemia. These TG rabbits were created by stable introduction of recombinant nucleic acid molecules.
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