A new study reveals that metformin, a widely prescribed diabetes medication, can significantly improve health parameters in aged male cynomolgus monkeys — possibly by slowing the aging process. The findings represent an important step toward understanding how pharmaceutical interventions might, in the future, extend the healthspan and delay age-related diseases in humans.
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References
Rolland, Y. et al. Nat. Commun. 14, 5038 (2023).
Harrison, D. E. et al. Nature 460, 392–395 (2009).
Colman, R. J. et al. Science 325, 201–204 (2009).
Mattison, J. A. et al. Nat. Commun. 8, 14063 (2017).
Yang, Y. et al. Cell https://doi.org/10.1016/j.cell.2024.08.021 (2024).
Lu, A. T. et al. Nat. Aging 3, 1144–1166 (2023).
Sampathkumar, N. K. et al. Hum. Genet. 139, 333–356 (2020).
Strong, R. et al. Aging Cell 15, 872–884 (2016).
Oh, H. S. et al. Nature 624, 164–172 (2023).
Walton, R. G. et al. Aging Cell 18, e13039 (2019).
Acknowledgements
The author would like to thank Alexander Tyshkovskiy (Brigham and Women’s Hospital and Harvard Medical School) for critical discussions about the work and its implications.
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Castro, J.P. Metformin and monkeys: what can we learn about delaying aging?. Lab Anim 54, 7–8 (2025). https://doi.org/10.1038/s41684-024-01492-2
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DOI: https://doi.org/10.1038/s41684-024-01492-2
