The functional characterization of proteins during temporally constrained periods of mammalian development and disease is largely limited by the inability to rapidly and reversibly perturb their function. A new study addresses this challenge by directly comparing two targeted protein degradation systems in mice. These systems enable precise temporal degradation of proteins, offering unprecedented opportunities to study dynamic biological processes. Several technical components remain to be optimized, but these technologies promise to provide novel insights in vivo.
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Scott, T.G., Guertin, M.J. Rapid protein degradation systems to determine gene function in vivo. Lab Anim 54, 66–67 (2025). https://doi.org/10.1038/s41684-025-01519-2
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DOI: https://doi.org/10.1038/s41684-025-01519-2
