Fig. 2: Heart rate and SA node properties are differentially affected by ISO and PEN in male and female rats. | Lab Animal

Fig. 2: Heart rate and SA node properties are differentially affected by ISO and PEN in male and female rats.

From: Differential effects of anesthetics and sex on supraventricular electrophysiology and atrial fibrillation substrate in rats

Fig. 2

a, Comparison of RR intervals under UAS, ISO and PEN, stratified by sex. Note prolongation of RR intervals by PEN relative to UAS and ISO in both males and females. b, Comparison between males and females of Δ change in the RR interval relative to UAS under ISO and PEN conditions. c, Comparison of CSNRT under UAS, ISO and PEN, stratified by sex. Note that, in males only, there was marked prolongation of CSNRT under ISO relative to both UAS and PEN. d, Comparison between males and females of Δ change in the CSNRT relative to UAS under ISO and PEN conditions. Statistical analysis: normality was confirmed in a and c; thus, one-way ANOVA for repeated measurements was applied, followed by post-hoc Tukey’s multiple-comparison test. Normality was confirmed in b and d; thus, an unpaired Student’s t-test was applied to compare males and females. In all panels, n = 13 for males and n = 16 for females. All data are expressed as mean ± s.e.m. *P < 0.05, **P < 0.01. n.s., not significant.

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