Extended Data Fig. 1: Complexity analysis of the rat atrial signal following ventricular signal subtraction. | Lab Animal

Extended Data Fig. 1: Complexity analysis of the rat atrial signal following ventricular signal subtraction.

From: Differential effects of anesthetics and sex on supraventricular electrophysiology and atrial fibrillation substrate in rats

Extended Data Fig. 1

An example of a recording before (left) and after (right) a burst pacing protocol leading to an arrhythmic event. I: peripheral ECG, II: original atrial recording. III: Cleaned atrial recording following ventricular signal subtraction based on QRS detection in the ECG38. Dashed line represents the complexity analysis threshold. IV: binary sequence derived from the crossing of the amplitude threshold by the pure atrial signal. Post-burst binary sequence was analyzed in 1-s windows using the Lempel-Ziv complexity (LZC) algorithm38 (see also METHODS for details). The final complexity ratio (CR) for each window was calculated as the post-burst LZC of this window divided by the pre-burst LZC. As we have previously shown, CR > 1.236 could detect irregular arrhythmic signals in a highly efficient manner (AUC = 96.3%, Sensitivity=94.5%, Specificity=93.1%)38.

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