Table 4 Calculated ranges of RIs for biochemical and hematological parameters as per the EP28-A3c guideline for Indian and Chinese rhesus macaques (Macaca mulatta) and cynomolgus macaques (Macaca fascicularis)

Indian Macaca mulatta

Biochemical

ALP

40

169.60

76.50

145.10

194.00

47.00

396.00

47.38

393.80

47.00–316.55

U/L

ALT

80

29.56

10.08

27.32

31.81

12.00

62.00

12.08

61.72

7.63–48.45

U/L

GGT

85

74.48

23.73

69.36

79.60

34.00

127.00

35.60

125.60

24.72–121.49

U/L

BA

82

0.67

0.55

0.55

0.79

0.00

3.00

0.00

1.00

0.00–1.00

µmol/L

TBIL

86

4.85

0.95

4.65

5.05

2.00

8.00

3.00

7.00

3.00–7.00

µmol/L

ALB

86

45.44

2.73

44.86

46.03

38.00

52.00

39.00

51.83

40.09–50.79

g/L

BUN

86

4.06

0.86

3.88

4.25

1.50

6.20

2.32

5.90

2.38–5.75

mmol/L

CHOL

86

3.13

0.48

3.03

3.24

1.90

4.20

2.32

4.08

2.19–4.08

mmol/L

Hematological

RBC

81

5.44

0.47

5.34

5.55

4.19

6.62

4.21

6.34

4.52–6.36

×10¹²/L

WBC

81

8.57

3.40

7.82

9.32

1.70

18.50

3.01

17.49

1.24–14.97

×10⁹/L

PLT

81

281.00

134.00

251.30

310.60

23.00

537.00

44.10

494.00

13.17–551.75

×10⁹/L

GRAN

79

3.91

1.84

3.50

4.32

1.00

10.10

1.30

8.20

1.00–7.40

×10⁹/L

LYM

81

3.71

2.14

3.24

4.18

0.30

10.40

0.71

9.69

0.30–7.80

×10⁹/L

MONO

81

0.74

0.40

0.66

0.83

0.00

2.10

0.10

1.80

0.00–1.50

×10⁹/L

HCT

76

36.03

3.01

35.34

36.71

28.40

41.50

28.86

40.95

30.06–42.37

%

HGB

75

13.06

0.90

12.85

13.26

10.20

15.10

10.74

14.56

11.35–14.96

g/dL

MCH

77

24.17

1.32

23.87

24.47

19.50

27.30

21.40

26.54

21.57–26.77

pg

MCV

77

66.83

2.93

66.17

67.50

59.40

73.90

59.88

72.48

61.09–72.57

fL

MCHC

77

36.18

1.70

35.79

36.56

32.80

39.50

32.90

39.22

32.69–39.62

g/dL

RDWa

77

44.35

2.42

43.80

44.89

38.70

50.30

39.94

49.26

39.62–49.08

fL

RDW%

62

20.37

0.71

20.19

20.55

18.90

22.20

18.96

22.20

18.98–21.76

%

MPV

76

7.96

0.80

7.78

8.15

6.40

9.70

6.68

9.61

6.39–9.53

fL

Chinese Macaca mulatta

Biochemical

ALP

34

390.20

138.70

341.80

438.60

162.00

718.00

162.00

718.00

72.82–658.66

U/L

ALT

34

26.44

7.56

23.80

29.08

13.00

48.00

13.00

48.00

11.63–41.25

U/L

GGT

34

67.35

25.56

58.43

76.27

24.00

118.00

24.00

118.00

17.25–117.45

U/L

BA

34

0.76

0.43

0.61

0.91

0.00

1.00

0.00

1.00

0.00–1.00

µmol/L

TBIL

34

7.79

2.33

6.98

8.61

3.00

12.00

3.00

12.00

2.93–12.70

µmol/L

ALB

34

47.09

4.49

45.52

48.65

38.00

56.00

38.00

56.00

38.29–55.89

g/L

BUN

34

4.72

0.83

4.43

5.01

3.00

6.50

3.00

6.50

3.10–6.35

mmol/L

CHOL

34

3.12

0.59

2.92

3.33

2.10

4.60

2.10

4.60

1.97–4.27

mmol/L

Hematological

RBC

34

4.51

0.26

4.42

4.60

4.05

5.25

4.05

5.25

4.00–5.02

×10¹²/L

WBC

35

7.47

2.16

6.73

8.21

3.30

11.90

3.30

11.90

3.24–11.69

×10⁹/L

PLT

35

155.80

92.39

124.10

187.60

32.60

381.00

32.60

381.00

32.60–345.41

×10⁹/L

GRAN

35

3.65

2.13

2.92

4.39

1.00

9.10

1.00

9.10

1.00–7.70

×10⁹/L

LYM

36

3.28

1.66

2.71

3.84

0.80

7.10

0.80

7.10

0.80–6.31

×10⁹/L

MONO

34

0.60

0.24

0.52

0.68

0.20

1.40

0.20

1.40

0.04–1.10

×10⁹/L

HCT

35

31.59

2.08

30.88

32.31

28.20

37.00

28.20

37.00

27.52–35.66

%

HGB

35

11.34

0.72

11.09

11.58

10.40

13.30

10.40

13.30

9.69–12.69

g/dL

MCH

36

25.00

1.09

24.63

25.37

22.80

27.40

22.80

27.40

22.87–27.13

pg

MCV

36

69.45

3.20

68.37

70.53

62.70

76.80

62.70

76.80

63.17–75.73

fL

MCHC

36

36.01

0.80

35.73

36.28

33.60

37.90

33.60

37.90

34.44–37.58

g/dL

RDWa

36

45.92

3.34

44.79

47.05

39.90

55.80

39.90

55.80

39.38–52.46

fL

RDW%

35

20.15

0.68

19.92

20.39

18.80

22.10

18.80

22.10

18.82–21.48

%

MPV

35

7.71

0.82

7.42

7.99

6.40

9.50

6.40

9.50

6.09–9.32

fL

Macaca fascicularis

Biochemical

ALP

20

223.30

122.50

165.90

280.60

78.00

448.00

78.00

448.00

78.00–463.40

U/L

ALT

21

35.57

14.07

29.17

41.98

20.00

65.00

20.00

65.00

2.40–64.66

U/L

GGT

21

47.38

14.70

40.69

54.07

25.00

74.00

25.00

74.00

18.57–76.19

U/L

BA

21

0.33

0.48

0.11

0.55

0.00

1.00

0.00

1.00

0.00–1.00

µmol/L

TBIL

21

4.91

0.94

4.48

5.33

4.00

8.00

4.00

8.00

4.00–8.00

µmol/L

ALB

21

43.19

2.73

41.95

44.43

38.00

47.00

38.00

47.00

37.84–48.54

g/L

BUN

21

6.45

0.86

6.06

6.84

4.50

7.60

4.50

7.60

4.77–8.14

mmol/L

CHOL

21

2.52

0.59

2.25

2.79

1.60

4.20

1.60

4.20

1.37–3.67

mmol/L

Hematological

RBC

22

5.34

0.52

5.11

5.57

4.58

6.56

4.58

6.56

4.32–6.37

×10¹²/L

WBC

22

10.53

2.63

9.37

11.70

5.90

15.10

5.90

15.10

5.39–15.68

×10⁹/L

PLT

22

272.20

108.70

224.00

320.40

33.00

447.00

33.00

447.00

67.18–531.84

×10⁹/L

GRAN

22

4.94

2.09

4.01

5.87

1.70

10.00

1.70

10.00

0.83–9.04

×10⁹/L

LYM

22

4.88

1.72

4.12

5.65

2.40

8.60

2.40

8.60

1.50–8.26

×10⁹/L

MONO

22

0.71

0.22

0.61

0.81

0.40

1.30

0.40

1.30

0.12–1.18

×10⁹/L

HCT

22

36.55

2.52

35.43

37.67

31.50

40.90

31.50

40.90

31.60–41.50

%

HGB

22

12.33

0.99

11.89

12.77

10.40

14.30

10.40

14.30

10.38–14.28

g/dL

MCH

22

23.16

0.99

22.72

23.60

21.50

24.90

21.50

24.90

21.22–25.10

pg

MCV

22

68.66

3.65

67.04

70.28

62.30

76.30

62.30

76.30

61.50–75.82

fL

MCHC

21

33.75

0.78

33.40

34.11

32.20

35.10

32.20

35.10

32.23–35.27

g/dL

RDWa

22

44.79

2.30

43.77

45.80

40.30

49.00

40.30

49.00

40.29–49.29

fL

RDW%

22

14.27

0.40

14.10

14.45

13.50

15.00

13.50

15.00

13.49–15.05

%

MPV

21

8.05

0.70

7.73

8.37

6.80

9.80

6.80

9.80

6.67–9.42

fL