Fig. 2: Impact of BPP on Iso, KX and KXO₂ protocols.

a,b, Mortality rate is described as the percentage of mice unable to recover from anesthesia over the total number of mice anesthetized, before (a) and after (b) BPP administration. c, A schematic representation of the experimental design to assess the effect of BPP in each of the three protocols. No surgery was performed in this experiment. d, Induction time, defined as the time passing from drug administration to loss of righting reflex, in all three groups without BPP administration. e, Nonsurgical tolerance, defined as the time passing from loss of righting reflex to loss of pedal reflex, in all three groups without BPP administration. f, Mortality rate in the three groups without BPP administration. In a, b and f, bars indicate the percentage of events with respect to the total number of animals forming each group (n = 3). In d and e, lines and points indicate mean and individual values, respectively.