Table 1 Diagnosis and treatment of aptamer versus antibody
Application | Aptamer | Antibody |
|---|---|---|
Internalizing into target cell | Efficiently internalization | Poor internalize into tumors |
Tumor sphere penetration | At least a 4-time better tumor penetration | Hardly penetration |
Tumor imaging in vivo | A much better clinically signal -to-background ratio | More slower uptake in target sites |
Drug delivery in vivo | 4.3-Fold longer of sustainable signal | Lower retention in tumor sites |
