Fig. 5: Clinical validation of PIBEX chip in liquid biopsy of breast cancer.
From: Precision cell-free DNA extraction for liquid biopsy by integrated microfluidics
The PIK3CA mutation in HER-2 type of breast cancer was monitored in liver metastasis using DNA extracted from the PIBEX chip. a Fraction change of PIK3CA H1047R mutation in ctDNA was detected by ddPCR. Each cancer therapy image is labeled with the background color of the graph. b Hepatic metastasis from breast cancer in abdominal MRI images. Red arrows indicate metastasis of breast cancer in liver. Inverted triangles of a represent the matching MRI images of b.
