Fig. 1: Expression profile of ICPs across multiple cancer types. | npj Precision Oncology

Fig. 1: Expression profile of ICPs across multiple cancer types.

From: Genomic investigation of co-targeting tumor immune microenvironment and immune checkpoints in pan-cancer immunotherapy

Fig. 1

a Expression profile of PD-L1 in multiple cancer types. GEPIA generated dot plots profiling the tissue-wise expression patterns of PD-L1 across multiple cancer types (TCGA tumor) and paired normal tissue samples (TCGA normal + GTEx normal). Each dot represents the individual expression of a distinct tumor or normal sample. b Summary of expression profiles of ICPs in multiple cancer types. Differential expression profiles of ICPs were individually analyzed using GEPIA and subsequently integrated together. Red blocks represent the ICPs upregulated in the tumor, green blocks represent the ICPs downregulated in the tumor, and blank blocks indicate the ones are not significantly differentially expressed between tumoral and normal tissues. ANOVA method was used for differential gene expression analysis, and genes with higher |log2FC| values (> 1) and lower q values (< 0.01) were considered differentially expressed genes.

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