Fig. 9: Immunological influence of ICD mediators on TILs across multiple cancer types. | npj Precision Oncology

Fig. 9: Immunological influence of ICD mediators on TILs across multiple cancer types.

From: Genomic investigation of co-targeting tumor immune microenvironment and immune checkpoints in pan-cancer immunotherapy

Fig. 9

a Correlations between CALR and TILs in multiple cancer types. b Correlations between LRP1 and TILs in multiple cancer types. c Correlations between ANXA1 and TILs in multiple cancer types. d Correlations between FPR1 and TILs in multiple cancer types. e Correlations between TLR3 and TILs in multiple cancer types. f Correlations between IFNAR1 and TILs in multiple cancer types. g Correlations between PANX1 and TILs in multiple cancer types. h Correlations between P2RX7 and TILs in multiple cancer types. TISIDB generated spearman correlations between expression of ICD mediators and an abundance of TILs across multiple cancers (TCGA tumor). The immune-related signatures of 28 TIL types were collected from Charoentong’s study. For each cancer type, the relative abundances of TILs were inferred by using gene set variation analysis based on gene expression profile. Each correlation between an ICD mediator and a distinct TIL in an individual cancer type was integrated into the indicated heatmap.

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