Table 3 Association between plasma levels of AFP, ANGPTL4, CXCL1, HGF, sCD40L, sEGFR, sTNFRII, sgp130, and sIL-6R and risk of death 3 months post SBRT.

From: Association of pro-inflammatory soluble cytokine receptors early during hepatocellular carcinoma stereotactic radiotherapy with liver toxicity

Plasma levels of soluble factors

At baseline

After 1 to 2 fractions of SBRT

HR

95% CI

P-value

HR

95% CI

P-value

AFP

2.16

1.03–4.54

0.043*

2.16

1.03–4.54

0.04*

ANGPTL4

1.10

0.58–2.09

0.76

1.11

0.58–2.10

0.75

CXCL1

0.78

0.41–1.46

0.43

0.69

0.37–1.31

0.26

HGF

0.91

0.40–2.04

0.82

1.15

0.51–2.59

0.75

sCD40L

0.52

0.27–0.99

0.05*

0.54

0.29–1.05

0.07

sEGFR

2.61

1.32–5.16

0.006*

1.80

0.93–3.48

0.08

sTNFRII

1.93

1.02–3.65

0.04*

2.27

1.19–4.34

0.01*

sgp130

2.19

1.13-4.25

0.021*

1.71

0.88–3.29

0.11

sIL-6R

1.90

1.01–3.57

0.05*

1.99

1.06–3.75

0.03*

  1. HR, hazard ratio; 95% CI, 95% confidence interval.
  2. *Statistical significance.
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