Fig. 2: Programs and states.
From: Genetic program activity delineates risk, relapse, and therapy responsiveness in multiple myeloma
a Heatmap of regulon activity across patients reveals distinct transcriptional states wherein patients have very similar regulon activity across the entire network. b, c Kaplan–Meier survival curves relating overexpression of each program (b) and state (c) to the observed progression-free survival in the CoMMpass study. The highest risk (red) and lowest risk (blue) programs are highlighted in (b). The four lowest risk (blue) and three highest risk (red) states are pooled to generate the highlighted curves in (c). d The risk distribution of each state according to the GuanRank of the survival data. States with fewer than five patients represented in the survival data were omitted. Center line, median; box limits, upper and lower quartiles; whiskers, 1.5× interquartile range. e Patients with t(4;14) or t(11;14) fall into several distinct transcriptional states with varying risk of disease progression. f Program activity sub-stratifies t(4;14) into standard and extreme-risk groups. g Kaplan–Meier plot of substratified t(4;14) groups.
