Fig. 4: Network activity.
From: Genetic program activity delineates risk, relapse, and therapy responsiveness in multiple myeloma
a, b Heatmaps of (a) normalized gene expression and (b) network activity for all genes appearing in at least two regulons. c Boxplots comparing the prediction of high-risk subsets using normalized expression (blue) or network activity (green) of the genes as features. Each point overlaying the boxplots is a mean area under the ROC curve (AUC) from 5-fold cross-validation of the high-risk prediction. One hundred iterations were performed for each condition to avoid bias in the selection of training and test subsets. Center line, median; box limits, upper and lower quartiles; whiskers, 1.5× interquartile range. d Kaplan–Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the predictions in (c).
