Fig. 6: Network activity of genes at baseline versus relapse.
From: Genetic program activity delineates risk, relapse, and therapy responsiveness in multiple myeloma
a Each point depicts the mean network activity of a gene at relapse versus baseline. The genes of programs Pr-134, Pr-68, Pr-34, Pr-4, and Pr-0 are highlighted. b, c Boxplots of (b) gene expression and (c) mean regulon activity at baseline and relapse for target genes of baseline therapy (IMiDs: CRBN, IKZF1, IKZF3; dexamethasone: NR3C1; carfilzomib: PSMB5). Center line, median; box limits, upper and lower quartiles; whiskers, 1.5× interquartile range.
