Table 1 Results of Ridge regression using regulon activity as features.

From: Genetic program activity delineates risk, relapse, and therapy responsiveness in multiple myeloma

Dataset

N

Median PFS

AUC

Spearman R

Spearman p

Cox HR

Cox p

MMRF IA12a

769

631

0.86

0.59

7.2E–72

19.1

5.2E–81

GSE24080

559

1288

0.70

0.26

5.4E–10

7.4

1.1E–13

GSE19784

282

782

0.71

0.35

1.4E–9

6.3

2.7E–10

  1. N number of samples, the median in days, Spearman correlation is predicted risk score versus GuanRank (i.e., observed risk rank), and Cox regression is with respect to the predicted risk score.
  2. aMMRF IA12 was used for training.
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