Fig. 1: Co-mutation plot showing association between clinical information and genomic characteristics. | npj Precision Oncology

Fig. 1: Co-mutation plot showing association between clinical information and genomic characteristics.

From: Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa

Fig. 1

Patients are represented by the columns ordered by decreasing ctDNA fraction. The top two rows show bar plots of tumor fractions estimated with ichorCNA from cfDNA sequenced with 30× WGS-cfDNA (gold bars) and 0.1× WGS-cfDNA (blue bars) (n = 15 patients). The horizontal line across the bar plot shows the limit of detection of ichorCNA for 0.1× (ctDNA fraction = 3%) and a threshold for 30x (ctDNA fraction = 1%) for the detection of ctDNA. Immunohistochemical stains for ER, PR and HER2+, age, and tumor size classification are presented. Copy number gain and loss of selected driver genes in breast cancers are shown in the bottom panel.

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