Fig. 4: In vivo tumorigenic potential of the NPM1–TYK2 fusion gene.
From: Functional characterization of NPM1–TYK2 fusion oncogene
A Representative image of mice (n = 6) subcutaneously injected with Ba/F3-Vector showed no tumors. B Representative images of mice (n = 6) subcutaneously injected with transformed Ba/F3–NPM1–TYK2 show tumorigenesis. C Representative images of resected tumors with their respective tumor weight (grams). D Tumor volume was increased significantly in transformed Ba/F3–NPM1–TYK2 injected mice but not in Ba/F3-Vector mice. Bars represent the SEM. E, F In transformed Ba/F3 (NPM1–TYK2) mice, tumor growth was associated with hepatosplenomegaly.
