Fig. 8: Loss of NPM1 partner abrogates NPM1–TYK2 transformation potential.
From: Functional characterization of NPM1–TYK2 fusion oncogene
A Deletion of NPM1 portion in NPM1–TYK2 fusion gene abrogates the transformation potential of the NPM1–TYK2 fusion gene in Ba/F3 cells. Ba/F3 cells were transduced with lentiviral particles expressing vector, NPM1–TYK2, and ΔN-1–257-NPM1–TYK2. Cells were grown in RPMI medium without IL-3 growth factor for 10 days. Cell viability from each condition was determined daily by trypan blue exclusion assay. Points represent the mean of three independent experiments; bars represent SEM. ∗∗∗P < 0.0005 was considered as statistically extremely significant. B The deletion of the NPM1 portion in the NPM1–TYK2 fusion gene inhibits the clonogenic potential. Columns represent the mean of three independent experiments; bars represent the SEM.
