Fig. 5: Diacetylspermine is elevated in breast cancer tissue, specifically in TNBC and HER2+ molecular subtypes. | npj Precision Oncology

Fig. 5: Diacetylspermine is elevated in breast cancer tissue, specifically in TNBC and HER2+ molecular subtypes.

From: Pharmacometabolomics reveals urinary diacetylspermine as a biomarker of doxorubicin effectiveness in triple negative breast cancer

Fig. 5

Breast cancer tumor vs matched non-tumor tissue levels of urea cycle (a), polyamine (b) and acetylated polyamine metabolites (c), n = 33. Urea cycle (d), polyamine (e) and acetylated polyamine (f) metabolites in breast cancer according to molecular subtype classification. g SAT1 mRNA expression in TCGA and h METABRIC studies were obtained from cBioPortal. Box and swarm plots represent interquartile range (IQR) with center median and 1.5× IQR whiskers. Similarly, violin plots contain center median (dashed line) and 1.5× IQR (dotted lines). Gene expression data are presented in violin plots with n values indicated in the figure. Significance was determined by two-sided Wilcoxon matched-pair or one-way ANOVA with Tukey’s test, *P < 0.05, **P < 0.01, ***P < 0.01, ****P < 0.0001.

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