Fig. 1: Pan-cancer landscape of AID-related mutations.

a Illustrative representation of AICDA expression and AID activity within normal B cells. For AID motifs, W = A/T; R = Purine; Y = Pyrimidine; K = G/T; M = C/A. b Frequency of the fraction of SNV mutations attributed to AID motifs or APOBEC motifs for each tumor type in the ICGC cohort; dotted lines indicate median values across all samples. Center line represents the median values; error bars represent the upper and lower quartiles and whiskers define the minimal and maximum values. c AID mutations produce higher selection intensity on driver genes on minor hotspot residues but there is a higher number of affected genes/residues than the ones generated by the APOBEC related signatures.