Fig. 2: N-linked glycosylation changes associated with loss of differentiation.
From: Rewiring of the N-Glycome with prostate cancer progression and therapy resistance
a Table demonstrating the number of annotated well-differentiated and poorly differentiated tumor regions for each patient. b Volcano plot comparison of all glycans in annotated well-differentiated tumor regions (n = 40) and annotated poorly differentiated tumor regions (n = 25) with 2361.8560 m/z and 2528.8833 m/z showing statistical significance between the two groups. c Scatter plot comparison of Gal3Fuc2Man3GlcNAc6 and Gal3Fuc1Neu5Ac1Man3GlcNAc6 between all well differentiated (n = 40) and poorly differentiated (n = 25) tumor regions. Statistics performed between each group by multiple, unpaired t test with p < 0.05 considered significant. The following system was used to denote significance: p < 0.05 (*), p < 0.01 (**), p < 0.0001 (***), p < 0.00001 (****). Error bars correspond to standard deviation. d Receiver operator characteristic (ROC) curve demonstrating the predictive power (AUC = 0.77, p = 0.0003) of Gal3Fuc2Man3GlcNAc6 and Gal3Fuc1Neu5Ac1Man3GlcNAc6 loss for identifying poor differentiation of glands.
