Fig. 3: N-linked glycosylation changes in hormonally-treated tumors.
From: Rewiring of the N-Glycome with prostate cancer progression and therapy resistance
a Table demonstrating number of hormone-sensitive and hormonally-treated PCa patients studied, the number of annotated tumor regions within each group, and number of significant glycans between all hormone-sensitive regions (n = 120) and all hormonally-treated regions (n = 37). b Volcano plot comparison of all glycans in annotated hormone sensitive PCa tumor regions (n = 120) and annotated hormonally-treated PCa tumor regions (n = 37). 105/150 glycans detected demonstrate statistical significance between the two groups with 30 structures upregulated and 75 structures downregulated. c Circle graph demonstrating the proportion of upregulated and downregulated glycans within each major structural category. Complex biantennary glycans represent the largest proportion of upregulated glycans while complex tri- and tetraantennary glycans represent the largest proportion of downregulated glycans. d Tables demonstrating common structural modifications associated with upregulated and downregulated N-glycans in each major structural class showing a significant change.
