Fig. 8: N-linked glycosylation changes associated with neuroendocrine differentiation.
From: Rewiring of the N-Glycome with prostate cancer progression and therapy resistance
a Table demonstrating number of annotated adenocarcinoma and NE tumor regions for each patient. b Volcano plot comparison of all glycans in annotated adenocarcinoma regions (n = 17) and annotated NE tumor regions (n = 38). 110/150 glycans detected demonstrate statistical significance between the two groups with all structures downregulated. c Circle graph demonstrating the proportion of downregulated glycans within each major structural category. The vast majority of downregulated glycans were complex-type with roughly equal proportions of complex bi-, tri-, and tetraantennary structures. d Table demonstrating common structural modifications associated with the downregulated N-glycans in each major structural class showing a significant change. e Scatter plot comparison of fucosylated and non-fucosylated Gal3Man3GlcNAc6 between all adenocarcinoma (n = 17) and NE (n = 38) tumor regions. Statistics performed between each group by multiple, unpaired t test with p < 0.05 considered significant. The following system was used to denote significance: p < 0.05 (*), p < 0.01 (**), p < 0.0001 (***), p < 0.00001 (****). Error bars correspond to standard deviation. f ROC curve demonstrating the predictive power (AUC = 0.9149, p < 0.0001) of fucosylated and non-fucosylated Gal3Man3GlcNAc6 for predicting NE differentiation.
