Fig. 2: c-Scorehi tumors are enriched in genes and pathways involved with the cancer-immunity cycle. | npj Precision Oncology

Fig. 2: c-Scorehi tumors are enriched in genes and pathways involved with the cancer-immunity cycle.

From: Chemokine expression predicts T cell-inflammation and improved survival with checkpoint inhibition across solid cancers

Fig. 2

a Degree of the significance of immunoregulatory gene expression between c-Scorehi versus c-Scorelo+med groups across 25 tumor types from TCGA. Wilcoxon rank-sum test, FDR adjusted. (b) Scores for and (c) degree of significance in eight genesets representing processes involved in the cancer-immunity cycle across c-Scorehi (n = 1735) and c-Scorelo+med (n = 4720) tumors in this dataset. For each pair, c-Scorelo+med tumors are on left, c-Scorehi tumors are on the right, as depicted in the inset. A.U. Arbitrary units, translated onto a positive scale (see Methods). Wilcoxon rank-sum test, FDR adjusted. X represents FDR > 0.05.

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