Fig. 3: Analysis of epithelial cell malignancy based on the CNV and K-means algorithms.

A The CNV analysis of the scRNA-seq data. The reference indicates Myeloid cells; yellow in Observation indicates the normal Myeloid cells; green indicates the epithelial cells; blue in the map indicates the loss of a DNA copy; red indicates an increased DNA copy. B clustering of the cells of “observation” in Figure A by K-means algorithm. C CNV score after K-means clustering. D The UMAP plot of the epithelial cells, where blue indicates malignant epithelial cells (1314), and black indicates non-malignant epithelial cells (5). E UMAP plot of malignant epithelial cell clustering. F Sankey diagram of the distribution of C1–C4 cell clusters in GC tissue samples.