Fig. 8: Effects of CXCR4 on in vivo GC tumor formation and liver metastasis.

A Morphological image of tumor formation experiment in nude mice; B Changes in tumor weight in each group of nude mice; C Changes in tumor volume in each group of nude mice (0 ~ 9d: P > 0.05; 12d: P = 0.0128; 15 ~ 21d: P < 0.0001); D Changes in body weight of each group of nude mice (0 ~ 3d: P > 0.05; 6d: P = 0.0173; 9 ~ 21d: P < 0.0001); E Morphology of the liver in each group of nude mice; F H&E staining to detect the number of metastatic liver nodules in each group of nude mice, scale bar = 100 μm. * indicates a significant difference compared to the sh-NC group, *p < 0.05, **p < 0.01, ***p < 0.001, with 6 nude mice in each group.