Fig. 1: Study workflow and characteristics of paired primary and recurrent glioma.
From: Distinct aneuploid evolution of astrocytoma and glioblastoma during recurrence
a Sixty-five paired primary and recurrent glioma samples including grade 2/3 (lower grade) astrocytoma (n = 11), grade 4 astrocytoma (n = 8) and GB (n = 46) were enrolled to perform the whole-exome sequencing. Copy number variations (CNVs) and single nucleotide variants (SNVs) were detected for further evaluating of aneuploidy, pathway enrichment. Survival analysis and immunohistochemistry (IHC) validation were also performed as depicted (Created with BioRender.com). b Diagnosis, pathological, and molecular characteristics of primary glioma patients. Each column represents a patient. c Surgery time of primary and recurrent glioma patients. Sixteen cases were classified into 14 astrocytoma (Astro) and 2 glioblastoma (GB) patients. d The correlation between the proportion of shared mutations and recurrence time in GB. r denotes Pearson correlation coefficient. P values were obtained from the F test.
