Fig. 2: Proteogenomic analysis of high-grade serous ovarian cancers (HGSOC) - characterization of enriched tumor collections. | npj Precision Oncology

Fig. 2: Proteogenomic analysis of high-grade serous ovarian cancers (HGSOC) - characterization of enriched tumor collections.

From: Proteogenomic analysis of enriched HGSOC tumor epithelium identifies prognostic signatures and therapeutic vulnerabilities

Fig. 2

a Single nucleotide variants (SNVs), insertion/deletion (indel), and structural variants (SVs) identified from whole genome sequencing (WGS) data from laser microdissection (LMD) enriched tumor (ET) cell populations compared to bulk tumor (BT) tissue collections from the same specimen (*p reflects significance of Spearman Rho). b Hierarchical analysis of consensus clusters calculated from top 25% most variably abundant proteins from HGSOC ET proteome data (n = 70). c Sankey plot illustrating the transition of molecular subtypes classified by ConsensusOV in BT and ET transcriptome data. d Correlation analysis of global proteome and transcriptome data (7209 protein:transcript pairs) in BT collections (Spearman Rho = 0.47) is significantly lower (Mann–Whitney U, MWU p = 0.0007) than the correlation (Spearman Rho = 0.52) in ET collections (7598 protein:transcript pairs).

Back to article page