Fig. 1: Establishment of metCRC patient-derived organoids recapitulates histological architecture of primary tissues. | npj Precision Oncology

Fig. 1: Establishment of metCRC patient-derived organoids recapitulates histological architecture of primary tissues.

From: A functional personalised oncology approach against metastatic colorectal cancer in matched patient derived organoids

Fig. 1

a Establishment rates of CRC PDOs from patient samples derived from primary and metastatic lesions. b Establishment rates of ptCRC PDOs based on tumour origin. c Establishment rates of mCRC PDOs stratified according to metastatic site. d Brightfield images of 14 generated CRC PDO lines, including three pairs of matched metCRC PDOs. Black scale bar = 50 µm; blue scale bar = 100 µm; red scale bar = 150 µm. e Summary of clinical data for metastatic colorectal cancer patients from which matched PDOs were established. (FOLFOXIRI, 5-fluorouracil + leucovorin + oxaliplatin + irinotecan; XELOX, capecitabine + oxaliplatin). f H&E staining of matched metCRC parental tumours and PDOs derived from the corresponding tissues. Black scale bar = 50 µm; white scale bar = 100 µm.

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