Table 1 Summary of IC₅₀ values for 10 drugs derived from single-drug dose-response assays in 10 CRC PDO lines

5-fluorouracil

8.66 ± 8.32

36.72 ± 15.1

18.54 ± 13.18

11.62 ± 4.05

69.63 ± 47.43

1.09 ± 0.23

194 ± 32.13

17.94 ± 9.58

46.51 ± 25.44

127.57 ± 24.1

53.23

426

Oxaliplatin

8.85 ± 5.9

24.55 ± 13.58

10.97 ± 1.36

2.62 ± 1.67

22.11 ± 9.78

1.04 ± 1.18

120.97 ± 32.18

10.28 ± 1.79

37.15 ± 22.62

14.26 ± 9.33

25.28

4.96

Leucovorin

N.D.

N.D.

N.D.

N.D.

N.D.

N.D.

N.D.

N.D.

N.D.

N.D.

N.D.

2.86

SN-38

0.00528 ± 0.00071

0.01656 ± 0.01551

0.00514 ± 0.0026

0.008 ± 0.002

0.2806 ± 0.19554

0.0059 ± 0.0003

0.37023 ± 0.03774

0.13 ± 0.18

0.16982 ± 0.16458

0.4289 ± 0.29754

0.14204

0.143

Regorafenib

8.66 ± 4.34

7.23 ± 4.83

2.64 ± 0.28

2.24 ± 0.98

2.24 ± 0.28

5.4 ± 3.25

9.34 ± 2.89

3.78 ± 1.05

7.85 ± 3.67

6.42 ± 4.47

5.58

8.08

Pemrametostat

285.2 ± 156

214.87 ± 169.81

5.61 ± 3.22

67.99 ± 46.55

89.82 ± 53.4

42.75 ± 35.17

N.D.

N.D.

160.15 ± 98.28

N.D.

123.77

3.54

TP-064

18.06 ± 9.02

8.38 ± 3.34

3.05 ± 1.05

15.83 ± 4.13

24.02 ± 5.95

10.72 ± 0.57

22.6 ± 13.02

6.92 ± 3.18

47.15 ± 11.18

38.14 ± 5.38

19.49

–

Decitabine

2.26 ± 2.43

48.17 ± 38.73

25.98 ± 16.58

133 ± 110.65

207.93 ± 16.46

18.53 ± 25.67

149.92 ± 122.97

251.88 ± 170.47

395.33 ± 252.84

N.D.

113.62

0.323

Entinostat

2.29 ± 1.79

3.17 ± 1.43

28.7 ± 1.41

1.11 ± 0.06

1.26 ± 0.3

0.73 ± 0.31

0.73 ± 0.12

5.26 ± 2.97

3.19 ± 1.09

1.51 ± 0.24

4.80

0.19

Vorinostat

0.67 ± 0.32

1.85 ± 0.7

1.27 ± 0.23

0.998 ± 0.179

0.63 ± 0.28

1.01 ± 1.46

1.07 ± 0.35

2.75 ± 1.19

1.43 ± 0.42

0.24 ± 0.08

1.19

1.2