Table 1 Patient characteristics in data cohorts

From: Development and validation of a deep learning-based microsatellite instability predictor from prostate cancer whole-slide images

 

Overall

 

Training set

Paired validation set

Temporal validation set

Variable

MSI-H, N = 138a

MSS, N = 5400a

p-valueb

MSI-H, N = 73a

MSS, N = 3942a

MSI-H, N = 34a

MSS, N = 139a

MSI-H, N = 31a

MSS, N = 1319a

Age at collection date

71 (65, 76)

66 (60, 73)

<0.001

71 (64, 76)

66 (60, 72)

71 (65, 76)

68 (61, 73)

69 (63, 77)

68 (61, 74)

 Unknown

14

892

–

6

524

1

16

7

352

Race

  

0.5

      

 Asian (%)

3 (4.2)

67 (2.7)

–

1 (2.9)

56 (2.9)

1 (4.8)

1 (1.3)

1 (6.7)

10 (2.0)

  Black or African American (%)

11 (15)

472 (19)

–

2 (5.7)

355 (19)

4 (19)

11 (15)

5 (33)

106 (21)

 White (%)

57 (80)

1942 (78)

–

32 (91)

1494 (78)

16 (76)

63 (84)

9 (60)

385 (77)

  Unknown

67

2919

–

38

2037

13

64

16

818

Histology

  

0.6

      

 Adenocarcinoma (%)

136 (99)

5315 (98)

–

71 (97)

3874 (98)

34 (100)

135 (97)

31 (100)

1306 (99)

 Carcinoma (%)

1 (0.7)

17 (0.3)

–

1 (1.4)

15 (0.4)

0 (0)

1 (0.7)

0 (0)

1 (<0.1)

  Neuroendocrine (%)

1 (0.7)

51 (0.9)

–

1 (1.4)

40 (1.0)

0 (0)

1 (0.7)

0 (0)

10 (0.8)

  Sarcoma (%)

0 (0)

3 (<0.1)

–

0 (0)

3 (<0.1)

–

–

–

–

 Small cell carcinoma (%)

0 (0)

14 (0.3)

–

0 (0)

10 (0.3)

0 (0)

2 (1.4)

0 (0)

2 (0.2)

Total gleason

  

<0.001

      

 7 (%)

5 (4.3)

878 (21)

–

3 (4.8)

692 (22)

0 (0)

9 (8.1)

2 (8.7)

177 (20)

 8 (%)

18 (15)

832 (20)

–

9 (15)

617 (20)

3 (9.4)

11 (9.9)

6 (26)

204 (22)

  9 (%)

61 (52)

2097 (50)

–

33 (53)

1605 (51)

17 (53)

51 (46)

11 (48)

441 (49)

 10 (%)

33 (28)

370 (8.9)

–

17 (27)

245 (7.8)

12 (38)

40 (36)

4 (17)

85 (9.4)

 Unknown

21

1223

–

11

783

2

28

8

412

Procedure type

  

0.5

      

 Ambiguous biopsy (%)

18 (13)

578 (11)

–

11 (15)

431 (12)

3 (9.1)

12 (8.9)

4 (13)

135 (10)

 Core needle biopsy (%)

80 (59)

2910 (56)

–

42 (58)

2009 (54)

18 (55)

77 (57)

20 (65)

824 (63)

 Resection + excisional (%)

38 (28)

1691 (33)

–

19 (26)

1293 (35)

12 (36)

46 (34)

7 (23)

352 (27)

 Unknown

2

221

–

1

209

1

4

0

8

  1. aMedian (IQR); n (%).
  2. bWilcoxon rank-sum test; Fisher’s exact test; Pearson’s χ2 test.
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