Fig. 1: Genomic landscape and mutational signature.
From: Molecular landscape and multi-omic measurements of heterogeneity in fetal adenocarcinoma of the lung
a Mutational landscape of FLAC (n = 20). Alteration frequencies are calculated per patient. b The box plot showed the comparison of tumor mutational Burdon (TMB) between H-FLAC and L-FLAC patients. The p value is calculated using Wilcoxon rank-sum test. Center line, median; box limits, upper and lower quartiles; whiskers, 1.5x interquartile range. c Comparison of mutated gene frequency between FLAC and EAC cohort. The p value is calculated using Fisher’s exact test. *p < 0.05; **p < 0.01; ***p < 0.001. d COSMIC mutational signatures inferred from somatic base changes in FLAC. The color of each cell or dot represents the median mutation burden of the signature in sample(s) that show the signature. The size of each dot represents the proportion of samples of each subtype that shows the mutational signature. SBS: Single Base Substitution signatures; DBS: Doublet base substitutions signatures. ID: small Insertions and Deletions signatures. e Recurrent somatic copy-number variations in H-FLAC and L-FLAC. Amplifications and deletions are plotted in red and blue, respectively.
