Fig. 3: Heterogeneity of genomic alterations.
From: Molecular landscape and multi-omic measurements of heterogeneity in fetal adenocarcinoma of the lung
a, b Phylogenetic tree sand phyloepigenetic trees of H-FLAC (a) and L-FLAC (b) based on somatic mutations and DNA methylation profiles, respectively. N: normal tissue sample. c The proportion of trunk/branch mutations in each patient based on phylogenetic trees. d The proportions of putative driver mutations (oncogenes and tumor suppressor genes) versus passenger mutations on the trunks and branches of all H-FLAC or L-FLAC patients. e Comparison of the proportions of putative driver mutations (oncogenes and tumor suppressor genes) on the trunks and branches per patients. The p value is calculated using Wilcoxon rank-sum test. Center line, median; box limits, upper and lower quartiles; whiskers, 1.5x interquartile range.
