Fig. 6: Identification and description of the RCD signature. | npj Precision Oncology

Fig. 6: Identification and description of the RCD signature.

From: Pan-cancer evaluation of regulated cell death to predict overall survival and immune checkpoint inhibitor response

Fig. 6

a Circos plot showing the development of RCD.Sig in bulk level. b Circos plot showing the development of RCD.Sig in single-cell level. c 285 genes were identified as the RCD.Sig by intersecting the 1955 candidate genes in bulk level and 4186 candidate genes at single-cell level. d The bar plot depicting the enriched Reactome pathways of the RCD.Sig. e The bar plot depicting the enriched KEGG pathways of RCD.Sig. f The bar plot depicting the enriched BP pathways of RCD.Sig. BP: biological process. g Spearman correlation of median RCD.Sig score and median TMB of each cancer type. The ssGSEA scores were calculated to estimate the activity level of the RCD.Sig for each sample in TCGA. h Spearman correlation of median RCD.Sig score and median ITH of each cancer type. i The heat map showing the Spearman correlation of the RCD.Sig score and the immune cell infiltration estimated by the MCP-counter algorithm across the cancer types. j The heat map depicting the Spearman correlation of the RCD.Sig score and the activity of the immunotherapy response signatures across the cancer types.

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