Fig. 6: Gallery of image patches classified with high confidence for each CMS class. | npj Precision Oncology

Fig. 6: Gallery of image patches classified with high confidence for each CMS class.

From: Image-based consensus molecular subtyping in rectal cancer biopsies and response to neoadjuvant chemoradiotherapy

Fig. 6

For each cohort (ARISTOTLE, SALZBURG, TCGA), we selected the 16 image patches (side 630 μm) from different patients, with highest probability score for each imCMS class (based on the ensemble model of experiment [E3a]). Visual interpretation confirms the existence of distinct morphological patterns within each predicted imCMS class. a imCMS1: increased lymphocytic infiltrates, poor tumor differentiation, focal mucin; b imCMS2: glandular differentiation with cribriform growth patterns and comedo-like necrosis associated with imCMS2; c imCMS3: glandular differentiation with ectatic mucin-filled glandular structures in combination with a minor component showing papillary and cribriform morphology; d imCMS4: prominent desmoplastic stromal reaction and dissociative tumor growth (tumor budding).

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