Fig. 6: Example of imaging with corresponding histology.
From: Combination of MRI-based prediction and CRISPR/Cas12a-based detection for IDH genotyping in glioma
a MRI images and GradCAM heatmaps for patient 02. b Corresponding HE of biopsy targets. c Statistical table of tumor position, cancer cell percentage, and tumor purity of biopsy targets. d Comparison of tumor purity between important regions and unimportant regions as estimated by GradCAM. Data are presented as the mean ± SD (n = 3). **p < 0.01 between important regions and unimportant regions. e The frequency of base substitutions within specific trinucleotide mutational contexts of each sample in patient 02. f Oncoplot of genes with highest counts of variants in multi-spot tumors. g Phylogenetic tree of patient 02 by iTOL. h Phylogenetic tree was constructed for patient 02 based on the maximum parsimony algorithm.
