Fig. 5: Use of the BCPS in breast cancer prognostication.
From: Development and validation of a gene expression-based Breast Cancer Purity Score
a, b In ER+/HER2− samples from the Brueffer dataset (n = 2277) 7-years overall survival was predicted using a multivariate Cox model with interactions including an ER and a Proliferation metagene with or without the BCPS. C-index (a) and 7-years AUC (b) were computed for the two models highlighting a performance improvement when the BCPS was included. c Association of the BCPS with pCR in on-treatment biopsies from the NeoTRIP dataset (n = 219). d BCPS quantified in the surgical samples of the NeoSPHERE trial was associated with DEFS. Two groups based on the BCPS median were identified and represented by Kaplan–Meier curves; differences were evaluated by log-rank test.
