Table 4 FFPE and Frozen tissue sample results with statistical analysis on the TCGA testing sets in (a) classification of aggressive and non-aggressive EC, (b) TMB prediction of the aggressive EC, and (c) TMB prediction of the non-aggressive EC
Task | Tissue | Method | Acc. | Sens. | Spec. | MeanSS | AUROC (μ ± σ) | Fisher’s test p-value |
|---|---|---|---|---|---|---|---|---|
(a) Classification of aggressive and non-aggressive EC | FFPE | TR-MAMIL | 0.88 | 0.96 | 0.71 | 0.84 | 0.86 ± 0.01 | <0.001*** |
Frozen | 0.89 | 0.93 | 0.84 | 0.88 | 0.87 ± 0.04 | <0.001*** | ||
(b) TMB prediction for the aggressive subtype | FFPE | TR-MAMIL | 0.68 | 0.83 | 0.54 | 0.69 | 0.61 ± 0.04 | <0.001*** |
Frozen | 0.72 | 0.71 | 0.73 | 0.72 | 0.69 ± 0.06 | <0.001*** | ||
(c) TMB prediction for the non-aggressive subtype | FFPE | TR-MAMIL | 0.75 | 1.00 | 0.57 | 0.79 | 0.65 ± 0.15 | 0.81 |
Frozen | 0.66 | 0.72 | 0.63 | 0.68 | 0.57 ± 0.08 | 0.022* |
