Table 1 List of genes undergoing ARSs in PCa between Black and White patients and functioning in tumorigenic pathways
Genes | Hallmark Gene Sets |
|---|---|
TANK, CD44, VEGFA, TNIP1, IFNGR2, TNC | TNFA_SIGNALING_VIA_NFKB |
KLF7, UGP2, WSB1, P4HA2, ZNF292, TGM2, VEGFA | HYPOXIA |
PPARG, STX5 | CHOLESTEROL_HOMEOSTASIS |
TUBD1, DLG1, SORBS2, SHROOM1, ATG4B, GSN | MITOTIC_SPINDLE |
BCAR3, UBE2D3, IFNGR2 | TGF_BETA_SIGNALING |
MYD88, CD44, IL7, HAX1, IFNGR2 | IL6_JAK_STAT3_SIGNALING |
RFC2 | DNA_REPAIR |
G3BP1, SS18, PML, MEIS2, HMGA1, SLC38A1 | G2M_CHECKPOINT |
CD44, PTK2, GSN | APOPTOSIS |
TCF7L2 | NOTCH_SIGNALING |
PTGER3, TANK, UCK1, PHLDB1, SLC27A1, PPARG, GPHN, RAB34 | ADIPOGENESIS |
CD44, RHOD, TGM2 | ESTROGEN_RESPONSE_EARLY |
PTGER3, FGFR3, CD44, LTF, CYP4F11, SERPINA1 | ESTROGEN_RESPONSE_LATE |
CDC14B, SMS, IQGAP2, MAK, ABCC4, UBE2I | ANDROGEN_RESPONSE |
PDLIM7, LDB3, KCNH2, CAMK2B, GSN | MYOGENESIS |
TOM1L1, COPE, NAPA | PROTEIN_SECRETION |
LGALS3BP, LY6E, IL7 | INTERFERON_ALPHA_RESPONSE |
MYD88, SERPING1, PML, LGALS3BP, LY6E, IL7, CIITA | INTERFERON_GAMMA_RESPONSE |
DLG1, KCNH2, PTK2, TRO, RSU1, YWHAH | APICAL_JUNCTION |
NTNG1 | APICAL_SURFACE |
PML, VEGFA | HEDGEHOG_SIGNALING |
ERAP2, SERPING1, GNB2, LTF, SERPINA1 | COMPLEMENT |
ATP6V0D1, ZBTB17, BANF1, POP4, VEGFA | UNFOLDED_PROTEIN_RESPONSE |
MYD88, IRAK4, CAMK4, PPP2R1B, UBE2D3 | PI3K_AKT_MTOR_SIGNALING |
HMBS, BCAT1, UBE2D3, RAB1A, TOMM40, RDH11 | MTORC1_SIGNALING |
HMGA1, RFC2 | E2F_TARGETS |
G3BP1, TARDBP, COX5A, SNRPD2 | MYC_TARGETS_V1 |
CD44, TGM2, RGS4, VEGFA, TNC | EPITHELIAL_MESENCHYMAL_TRANSITION |
P2RX4, LY6E, IFNGR2, PTAFR | INFLAMMATORY_RESPONSE |
BCAT1, ESR1, ABCC3, HSD11B1, NDRG2, CYFIP2, CSAD, HACL1 | XENOBIOTIC_METABOLISM |
SMS, SDHD, ACOT8, RDH11, ACAA1, YWHAH | FATTY_ACID_METABOLISM |
ETFA, ATP6V0B, SDHD, MTRF1, COX5A, ACAA1 | OXIDATIVE_PHOSPHORYLATION |
UGP2, CD44, P4HA2, ZNF292, SLC35A3, VEGFA, HAX1 | GLYCOLYSIS |
TXNRD2 | REACTIVE_OXYGEN_SPECIES_PATHWAY |
BLCAP, MDM2, IP6K2, CYFIP2 | P53_PATHWAY |
DLG4, WIZ, KCNH2, NTRK3, NAT1, ACAA1, PTPRD | UV_RESPONSE_UP |
DLG1, PPARG, RGS4 | UV_RESPONSE_DN |
PTK2, VEGFA | ANGIOGENESIS |
SNCA, HMBS, P4HA2, CAST, PPOX | HEME_METABOLISM |
KLF7, SERPING1, GNB2, SERPINA1, GSN | COAGULATION |
CD44, RHOH, P2RX4, TGM2, IKZF2 | IL2_STAT5_SIGNALING |
BCAR3, HSD17B6, ABCD3, HACL1, SLC27A5 | BILE_ACID_METABOLISM |
DLG4, ACOT8, ABCD3, SLC25A17, CDK7, RDH11, ACAA1, YWHAH | PEROXISOME |
BCAT1, ITGAL, DYRK3, RPS9, IL7, IFNGR2 | ALLOGRAFT_REJECTION |
ZC3H14, MLF1, CAMK4, SNAP91, PGS1 | SPERMATOGENESIS |
EPB41L3, HSD11B1, EVI5, SNAP91, PRKG2, LCP1 | KRAS_SIGNALING_UP |
MFSD6, FGFR3, DTNB, THNSL2, SLC25A23, ZNF112 | KRAS_SIGNALING_DN |
PAK3 | PANCREAS_BETA_CELLS |
