Table 6 Physician-choice arm Predicted Drugs (treatment was administered blinded to test results)
Patient no. | Treatment received | ChemoID cytotoxic profile for Bulk of Tumor (high cell kill: > 50%; low cell kill: <50%) | ChemoID cytotoxic profile for CSCs (high cell kill: > 50%; low cell kill: <50%) | Response as per RECIST 1.1 criteria |
|---|---|---|---|---|
1 | Doxorubicin | Docetaxel/Carboplatin 78.7; Docetaxel 73.8; Doxorubicin/Carboplatin 61.6; Paclitaxel/Carboplatin 52.9; Gemcitabine/Cisplatin 40.1; Paclitaxel 32.9; Doxorubicin 32.1; Topotecan 31.7; Cisplatin 30.1; Gemcitabine/Carboplatin 24.0; Carboplatin 12.5; Gemcitabine <10 | Docetaxel/Carboplatin 54.1; Doxorubicin/Carboplatin 51.2; Docetaxel 49.8; Paclitaxel/Carboplatin 45.0; Gemcitabine/Cisplatin 40.9; Paclitaxel 40.1; Doxorubicin 29.1; Cisplatin 19.8; Gemcitabine/Carboplatin 17.9; Topotecan 16.9; Carboplatin <10; Gemcitabine <10 | PD |
2 | Doxorubicin | Gemcitabine/Cisplatin 46.6; Docetaxel/Carboplatin 41.6; Doxorubicin/Carboplatin 35.2; Cisplatin 33.3; Doxorubicin 31.7; Paclitaxel 27.3; Paclitaxel/Carboplatin 26.8; Gemcitabine/Carboplatin 21.2 Docetaxel 21.0; Gemcitabine 18.4; Carboplatin 16.5; Topotecan 10.3 | Doxorubicin/Carboplatin 69.6; Docetaxel/Carboplatin 63.3; Paclitaxel/Carboplatin 59.4; Gemcitabine/Cisplatin 48.7; Cisplatin 41.3; Topotecan 39.4; Doxorubicin 38.9; Docetaxel 36.2; Paclitaxel 35.0; Gemcitabine/Carboplatin 27.2; Gemcitabine 12.5; Carboplatin <10 | PD |
3 | Paclitaxel/Carboplatin | Docetaxel/Carboplatin 62.1; Docetaxel 61.4; Paclitaxel/Carboplatin 57.3; Paclitaxel 42.8; Doxorubicin/Carboplatin 42.7; Gemcitabine/Cisplatin 41.4; Cisplatin 36.5; Doxorubicin 30.3; Topotecan 22.7; Gemcitabine/Carboplatin 10.2; Carboplatin <10; Gemcitabine <10 | Docetaxel/Carboplatin 45.8; Paclitaxel/Carboplatin 43.0; Paclitaxel 42.7; Gemcitabine/Cisplatin 32.1; Cisplatin 30.8; Doxorubicin 27.3; Docetaxel 27.1; Carboplatin 16.2; Gemcitabine 14.1; Doxorubicin/Carboplatin <10; Topotecan <10 | PD |
4 | Doxorubicin | Docetaxel/Carboplatin 63.5; Gemcitabine/Cisplatin 56.0; Paclitaxel/Carboplatin 52.6; Docetaxel 46.0; Cisplatin 39.4; Topotecan 38.2 Doxorubicin/Carboplatin 35.7; Paclitaxel 34.5; Gemcitabine/Carboplatin 22.5; Carboplatin <10; Doxorubicin <10; Gemcitabine <10 | Docetaxel/Carboplatin 42.6; Gemcitabine/Cisplatin 33.5; Paclitaxel/Carboplatin 31.2; Docetaxel 26.5; Paclitaxel/Carboplatin 22.3; Cisplatin 21.6; Topotecan 17.0; Doxorubicin/Carboplatin 15.7; Paclitaxel 12.0; Gemcitabine/Carboplatin <10; Carboplatin <10; Doxorubicin <10; Gemcitabine <10 | PD |
5 | Doxorubicin/Carboplatin | Gemcitabine/Cisplatin 68.0; Doxorubicin 52.6; Docetaxel/Carboplatin 50.1; Cisplatin 49.8; Gemcitabine/Carboplatin 46.6; Doxorubicin/Carboplatin 45.0; Doxorubicin 45.0; Docetaxel 30.6; Paclitaxel/Carboplatin 28.8; Gemcitabine 26.5; Paclitaxel 21.8; Topotecan 10.4; Carboplatin <10 | Docetaxel/Carboplatin 61.3; Doxorubicin 56.7; Paclitaxel 52.0; Doxorubicin 48.7; Gemcitabine 47.9; Paclitaxel/Carboplatin 47.5; Carboplatin 46.9; Doxorubicin/Carboplatin 40.3; Paclitaxel 39.8; Gemcitabine/Cisplatin 38.4; Docetaxel 37.1; Gemcitabine/Carboplatin 30.9; Cisplatin 28.0; Topotecan 18.6 | PD |
6 | Docetaxel | Topotecan 45.1; Docetaxel/Carboplatin 43.4; Docetaxel 39.7; Paclitaxel 29.9; Paclitaxel/Carboplatin 27.9; Carboplatin 24.0; Doxorubicin 19.0; Carboplatin 16.4; Gemcitabine 16.3; Gemcitabine/Cisplatin 16.1; Doxorubicin/Carboplatin 14.9; Cisplatin 14.8; Gemcitabine/Carboplatin 12.1 | Cisplatin 27.3; Doxorubicin 25.8; Paclitaxel/Carboplatin 11.2; Carboplatin <10; Paclitaxel <10; Docetaxel <10; Gemcitabine <10; Docetaxel/Carboplatin <10; Topotecan <10 | PD |
7 | Gemcitabine/Carboplatin | Cisplatin 24.8; Docetaxel/Carboplatin 20.6; Gemcitabine/Cisplatin 19.8; Paclitaxel/Carboplatin 16.7; Doxorubicin 14.2; Doxorubicin/Carboplatin 14.1; Paclitaxel <10; Docetaxel <10; Gemcitabine <10; Carboplatin <10; Topotecan <10; Gemcitabine/Carboplatin <10 | Doxorubicin/Carboplatin 49.4; Paclitaxel/Carboplatin 45.7; Docetaxel 41.6; Paclitaxel 36.7; Docetaxel/Carboplatin 33.3; Gemcitabine/Cisplatin 32.5; Paclitaxel 29.7; Topotecan 29.3; Cisplatin 25.1; Doxorubicin 16.5; Carboplatin 10.2; Gemcitabine 10.2; Gemcitabine/Carboplatin <10 | PD |
8 | Topotecan | Paclitaxel/Carboplatin 47.1; Docetaxel/Carboplatin 33.3; Doxorubicin/Carboplatin 32.3; Gemcitabine/Cisplatin 25.2; Docetaxel 24.4; Topotecan 22.9; Gemcitabine/Carboplatin 18.1; Cisplatin 16.8; Carboplatin 14.1; Paclitaxel 11.3; Doxorubicin <10; Paclitaxel <10; Gemcitabine <10 | Doxorubicin/Carboplatin 69.0; Docetaxel 59.9; Paclitaxel/Carboplatin 50.9; Doxorubicin 50.4; Cisplatin 42.4; Paclitaxel 32.7; Topotecan 27.4; Carboplatin 20.4 | PD |
9 | Paclitaxel | Doxorubicin/Carboplatin 83.5; Doxorubicin 80.4; Gemcitabine/Cisplatin 79.9; Cisplatin 75.2; Docetaxel/Carboplatin 71.9; Docetaxel 61.4; Paclitaxel/Carboplatin 51.3; Gemcitabine/Carboplatin 45.3; Paclitaxel 28.7; Topotecan 24.2; Carboplatin 12.9; Gemcitabine <10 | Docetaxel/Carboplatin 82.3; Docetaxel 81.4; Paclitaxel/Carboplatin 63.8; Doxorubicin/Carboplatin 61.9; Gemcitabine/Cisplatin 52.1; Topotecan 50.4; Cisplatin 44.8; Doxorubicin 41.2; Paclitaxel 29.4; Gemcitabine 10.5; Gemcitabine/Carboplatin 10.2; Carboplatin <10 | PD |
10 | Paclitaxel/Carboplatin | Docetaxel/Carboplatin 76.7; Docetaxel 62.4; Gemcitabine/Cisplatin 62.0; Paclitaxel/Carboplatin 58.3; Gemcitabine/Carboplatin 51.3; Cisplatin 42.7; Doxorubicin/Carboplatin 38.1; Paclitaxel 35.2; Carboplatin 32.4; Doxorubicin 26.8; Topotecan <10; Gemcitabine <10 | Gemcitabine/Cisplatin 48.4; Doxorubicin 45.2; Cisplatin 41.4; Paclitaxel 39.9; Carboplatin 39.8; Gemcitabine/Carboplatin 35.5; Gemcitabine 35.2; Docetaxel 27.0; Docetaxel/Carboplatin 23.1; Paclitaxel/Carboplatin 13.1 | PD |
11 | Paclitaxel | Doxorubicin/Carboplatin 51.5; Paclitaxel/Carboplatin 49.1; Topotecan 48.3; Docetaxel/Carboplatin 45.7; Docetaxel 39.9; Gemcitabine/Cisplatin 37.7; Cisplatin 34.9; Gemcitabine/Carboplatin 30.1; Carboplatin 23.8; Gemcitabine 19.7; Paclitaxel 19.3; Carboplatin17.5; Doxorubicin 15.5 | Docetaxel/Carboplatin 61.2; Doxorubicin/Carboplatin 60.4; Paclitaxel/Carboplatin 58.1; Topotecan 50.5; Docetaxel 46.7; Cisplatin 46.2; Gemcitabine/Cisplatin 45.5; Paclitaxel/Carboplatin 37.7; Doxorubicin 28.7; Paclitaxel 29.3; Gemcitabine/Carboplatin 27.6; Carboplatin 17.5; Gemcitabine 14.6 | PD |
12 | Carboplatin | Gemcitabine/Cisplatin 68.0; Doxorubicin 62.6; Docetaxel/Carboplatin 60.5; Cisplatin 49.8; Gemcitabine/Carboplatin 45.6; Doxorubicin/Carboplatin 45.0; Docetaxel 27.3; Paclitaxel/Carboplatin 22.8; Gemcitabine 16.3; Paclitaxel 16.0; Topotecan 10.2; Carboplatin <10 | Docetaxel/Carboplatin 55.3; Doxorubicin 52.3; Paclitaxel 50.1; Doxorubicin 42.3; Gemcitabine 40.1; Paclitaxel/Carboplatin 37.9; Carboplatin 38.2; Doxorubicin/Carboplatin 37.8; Paclitaxel 36.2; Gemcitabine/Cisplatin 29.3; Docetaxel 29.0; Gemcitabine/Carboplatin 27.8; Cisplatin 12.0; Carboplatin <10; Topotecan <10 | PD |
13 | Gemcitabine | Gemcitabine/Cisplatin 51.6; Doxorubicin 37.9; Docetaxel 34.0; Cisplatin 30.8; Docetaxel/Carboplatin 29.9; Gemcitabine/Carboplatin 26.4; Carboplatin 18.8; Doxorubicin/Carboplatin 15.5; Paclitaxel 14.9; Paclitaxel/Carboplatin 13.7; Gemcitabine 11.3; Topotecan <10 | Gemcitabine/Cisplatin 44.3; Doxorubicin 38.9; Docetaxel 37.1; Cisplatin 35.4; Docetaxel/Carboplatin 38.1; Gemcitabine/Carboplatin 30.0; Carboplatin 27.3; Doxorubicin/Carboplatin 22.2; Paclitaxel 11.4; Paclitaxel/Carboplatin 10.3; Gemcitabine <10; Topotecan <10 | PD |
14 | Doxorubicin | Docetaxel 40.9; Paclitaxel/Carboplatin 12.7; Cisplatin 12.7; Doxorubicin 11.9; Paclitaxel 11.7; Carboplatin <10; Gemcitabine <10; Doxorubicin/Carboplatin <10 | Docetaxel 31.2; Paclitaxel/Carboplatin 11.4; Cisplatin 11.0; Doxorubicin <10; Paclitaxel <10; Carboplatin <10; Gemcitabine <10; Doxorubicin/Carboplatin <10 | PD |
15 | Doxorubicin | Docetaxel/Carboplatin 74.0; Doxorubicin/Carboplatin 73.9; Docetaxel 73.5; Doxorubicin 49.2; Gemcitabine/Cisplatin 39.9; Paclitaxel/Carboplatin 34.8; Cisplatin 34.4; Paclitaxel 18.9; Carboplatin 11.0; Gemcitabine/Carboplatin 11.0; Topotecan 10.4; Gemcitabine <10 | Doxorubicin/Carboplatin 93.6; Paclitaxel/Carboplatin 91.5; Docetaxel/Carboplatin 89.7; Gemcitabine/Cisplatin 83.0; Cisplatin 72.0; Docetaxel 70.5; Gemcitabine/Carboplatin 59.9; Paclitaxel 55.3; Doxorubicin 32.1; Carboplatin 28.0; Gemcitabine 20.0; Topotecan 18.7; Carboplatin <10 | PD |
16 | Paclitaxel | Doxorubicin/Carboplatin 92.4; Gemcitabine/Cisplatin 90.0; Paclitaxel/Carboplatin 89.4; Cisplatin 86.8; Doxorubicin 83.2; Gemcitabine/Carboplatin 70.6; Docetaxel/Carboplatin 69.9; Carboplatin 60.6; Docetaxel 47.4; Paclitaxel 25.3; Topotecan 18.6; Gemcitabine <10 | Paclitaxel/Carboplatin 86.5; Gemcitabine/Cisplatin 83.2; Doxorubicin/Carboplatin 82.7; Cisplatin 77.8; Docetaxel/Carboplatin 72.0; Gemcitabine/Carboplatin 64.8; Doxorubicin 64.8; Docetaxel 58.3; Carboplatin 40.7; Paclitaxel 34.1; Topotecan 23.9; Gemcitabine <10 | PD |
17 | Gemcitabine/Carboplatin | Docetaxel/Carboplatin 53.2; Carboplatin 43.1; Doxorubicin 41.4; Gemcitabine 39.4; Paclitaxel/Carboplatin 38.0; Gemcitabine/Cisplatin 34.2; Cisplatin 32.6; Paclitaxel 31.3; Doxorubicin/Carboplatin 28.0; Docetaxel 24.2; Gemcitabine/Carboplatin 24.0; Topotecan <10 | Docetaxel/Carboplatin 60.8; Topotecan 52.6; Paclitaxel 48.6; Doxorubicin/Carboplatin 45.2; Paclitaxel/Carboplatin 44.6; Docetaxel 37.3; Doxorubicin 32.9; Gemcitabine/Cisplatin 32.4; Cisplatin 19.7; Gemcitabine/Carboplatin 16.5; Gemcitabine 10.6; Carboplatin <10 | PD |
18 | Gemcitabine/Carboplatin | Docetaxel/Carboplatin 80.1; Docetaxel 70.0; Gemcitabine/Cisplatin 59.9; Doxorubicin/Carboplatin 51.8; Paclitaxel/Carboplatin 50.3; Doxorubicin 45.2; Paclitaxel 43.7; Cisplatin 38.4; Gemcitabine/Carboplatin 30.0; Paclitaxel 29.9; Gemcitabine 19.7; Carboplatin 15.4; Topotecan <10 | Docetaxel /Carboplatin 62.4; Docetaxel 52.0; Paclitaxel/Carboplatin 39.7; Doxorubicin 37.1; Gemcitabine 28.9; Docetaxel 24.6; Topotecan 22.0; Paclitaxel 20.6; Gemcitabine/Carboplatin 15.4 | PD |
19 | Doxorubicin | Gemcitabine/Cisplatin 89.0; Paclitaxel/Carboplatin 76.3; Cisplatin 70.4; Doxorubicin/Carboplatin 66.4; Docetaxel 61.6; Docetaxel/Carboplatin 60.1; Paclitaxel/Carboplatin 51.2; Gemcitabine/Carboplatin 49.7; Paclitaxel 49.5; Doxorubicin 33.8; Paclitaxel 26.1; Carboplatin 18.8; Topotecan 18.8; Gemcitabine <10 | Doxorubicin/Carboplatin 68.7; Gemcitabine/Carboplatin 67.8; Cisplatin 58.0; Docetaxel 56.8; Paclitaxel/Carboplatin 44.8; Doxorubicin 51.2; Docetaxel/Carboplatin 46.2; Topotecan 44.3; Gemcitabine/Carboplatin 36.9; Paclitaxel 29.3; Gemcitabine 15.6; Carboplatin 15.5 | PD |
20 | Doxorubicin | Doxorubicin/Carboplatin 76.6; Gemcitabine/Cisplatin 642; Docetaxel/Carboplatin 54.4; Cisplatin 42.2; Docetaxel 29.3; Doxorubicin 27.9; Doxorubicin 28.4; Paclitaxel/Carboplatin 27.8; Paclitaxel 19.0; Gemcitabine/Carboplatin 18.8; Paclitaxel 14.3; Carboplatin 10.7; Topotecan <10; Gemcitabine <10 | Doxorubicin/Carboplatin 77.9; Cisplatin 62.7; Gemcitabine/Cisplatin 62.5; Docetaxel/Carboplatin 34.8; Doxorubicin 31.9; Docetaxel 26.9; Carboplatin 26.1; Gemcitabine 22.3 | PD |
21 | Gemcitabine/Cisplatin | Docetaxel/Carboplatin 58.8; Doxorubicin/Carboplatin 41.5; Gemcitabine/Cisplatin 37.3; Paclitaxel/Carboplatin 32.2; Doxorubicin 29.7; Cisplatin 29.0; Gemcitabine/Carboplatin 26.5; Docetaxel 25.9; Doxorubicin 20.8; Paclitaxel 20.1; Topotecan 19.7; Carboplatin 13.6; Gemcitabine <10 | Docetaxel/Carboplatin 64.3; Doxorubicin/Carboplatin 59.0; Paclitaxel/Carboplatin 53.4; Docetaxel 52.8; Topotecan 47.7; Gemcitabine/Cisplatin 43.2; Paclitaxel 36.1; Doxorubicin 30.4; Cisplatin 27.6; Gemcitabine/Carboplatin 19.5; Gemcitabine <10; Carboplatin <10 | PD |
22 | Docetaxel | Docetaxel/Carboplatin 58.4; Gemcitabine/Cisplatin 51.0; Cisplatin 49.3; Docetaxel 45.4; Doxorubicin/Carboplatin 41.4; Paclitaxel/Carboplatin 35.1; Gemcitabine/Carboplatin 30.3 Topotecan 21.8 Doxorubicin 20.7; Paclitaxel 15.2; Carboplatin <10; Gemcitabine <10 | Docetaxel/Carboplatin 69.1; Paclitaxel/Carboplatin 68.1; Gemcitabine/Cisplatin 62.5; Paclitaxel/Carboplatin 45.2; Docetaxel 44.9; Cisplatin 44.0; Doxorubicin/Carboplatin 43.9; Topotecan 40.5; Gemcitabine/Carboplatin 31.0; Paclitaxel 23.0; Doxorubicin 17.8; Gemcitabine 13.0; Carboplatin <10 | PD |
23 | Doxorubicin | Doxorubicin/Carboplatin 89.9; Gemcitabine/Cisplatin 74.9; Cisplatin 74.9; Gemcitabine/Carboplatin 72.1; Paclitaxel/Carboplatin 61.0; Doxorubicin 49.7; Docetaxel/Carboplatin 45.4; Docetaxel 42.1; Paclitaxel 29.4; Topotecan 25.4; Carboplatin <10; Gemcitabine <10 | Doxorubicin/Carboplatin 65.4; Gemcitabine/Cisplatin 62.3; Cisplatin 52.3; Gemcitabine/Carboplatin 38.6; Paclitaxel/Carboplatin 37.1; Doxorubicin 28.9; Docetaxel/Carboplatin 22.0; Docetaxel 20.6; Paclitaxel/Carboplatin 20.1; Paclitaxel 18.3; Topotecan <10; Carboplatin <10; Gemcitabine <10 | PD |
24 | Doxorubicin | Docetaxel/Carboplatin 65.2; Doxorubicin/Carboplatin 52.5; Docetaxel 49.7; Paclitaxel/Carboplatin 49.3; Topotecan 41.0; Paclitaxel 29.9; Gemcitabine/Cisplatin 28.6; Paclitaxel/Carboplatin 20.9; Cisplatin 20.8; Doxorubicin 14.6; Paclitaxel 11.6; Gemcitabine/Carboplatin <10; Gemcitabine <10; Carboplatin <10 | Docetaxel/Carboplatin 52.9; Docetaxel 50.4; Doxorubicin/Carboplatin 47.2; Paclitaxel/Carboplatin 43.4; Paclitaxel 32.8; Topotecan 23.0; Doxorubicin 19.4; Gemcitabine/Cisplatin 18.7; Cisplatin 14.4; Gemcitabine/Carboplatin <10; Gemcitabine <10; Carboplatin <10 | PD |
25 | Doxorubicin | Doxorubicin/Carboplatin 55.7; Docetaxel 53.0; Docetaxel/Carboplatin 49.8; Paclitaxel/Carboplatin 47.1; Paclitaxel 39.2; Topotecan 36.1; Gemcitabine/Cisplatin 28.9; Doxorubicin 28.1; Cisplatin 26.5; Gemcitabine/Carboplatin 11.2; Carboplatin <10; Gemcitabine <10 | Doxorubicin/Carboplatin 71.0; Gemcitabine/Cisplatin 64.5; Docetaxel/Carboplatin 60.8; Doxorubicin 60.7; Docetaxel 50.6; Paclitaxel 49.4; Cisplatin 42.9; Paclitaxel/Carboplatin 40.8; Gemcitabine/Carboplatin 19.6; Carboplatin 12.7; Gemcitabine 10.5; Topotecan <10 | PD |
26 | Doxorubicin | Doxorubicin/Carboplatin 63.4; Gemcitabine/Cisplatin 62.3; Cisplatin 50.6; Gemcitabine/Carboplatin 38.6; Paclitaxel/Carboplatin 37.1; Doxorubicin 28.9; Docetaxel/Carboplatin 22.0; Docetaxel 20.6; Paclitaxel 18.3; Topotecan <10; Carboplatin <10; Gemcitabine <10 | Docetaxel/Carboplatin 60.5; Paclitaxel/Carboplatin 56.0; Carboplatin 47.6; Gemcitabine 40.0; Doxorubicin/Carboplatin 39.1; Gemcitabine/Cisplatin 38.6; Docetaxel 37.2; Doxorubicin 22.5; Cisplatin 15.0; Paclitaxel 13.5; Gemcitabine/Carboplatin 13.0; Topotecan <10 | PD |
27 | Doxorubicin | Gemcitabine/Cisplatin 52.2; Cisplatin 46.6; Paclitaxel/Carboplatin 43.6; Gemcitabine/Carboplatin 42.0; Docetaxel/Carboplatin 39.1; Doxorubicin/Carboplatin 36.9; Paclitaxel 35.5; Docetaxel 34.7; Doxorubicin 29.4; Gemcitabine 26.1; Carboplatin 24.6; Topotecan 15.0 | Gemcitabine/Cisplatin 55.9; Docetaxel/Carboplatin 54.8; Docetaxel 45.2; Paclitaxel/Carboplatin 44.8; Cisplatin 42.1; Doxorubicin/Carboplatin 41.2; Doxorubicin 39.8; Gemcitabine/Carboplatin 36.4; Gemcitabine 35.3; Paclitaxel 33.1; Topotecan 24.9; Carboplatin 10.5 | PD |
28 | Doxorubicin | Docetaxel/Carboplatin 73.5; Docetaxel 67.2; Doxorubicin/Carboplatin 66.4; Doxorubicin 58.1; Gemcitabine/Cisplatin 53.5; Cisplatin 38.4; Paclitaxel/Carboplatin 27.8; Topotecan 18.6; Gemcitabine/Carboplatin 11.7; Carboplatin <10; Gemcitabine <10; Paclitaxel <10 | Docetaxel/Carboplatin 48.6; Docetaxel 40.8; Doxorubicin 10.5; Paclitaxel/Carboplatin <10; Carboplatin <10; Gemcitabine <10; Doxorubicin/Carboplatin <10; Topotecan <10; Paclitaxel <10; Cisplatin <10; Carboplatin <10 | PD |
29 | Paclitaxel | Doxorubicin/Carboplatin 57.8; Docetaxel/Carboplatin 56.6; Docetaxel 56.1; Paclitaxel/Carboplatin 47.5; Gemcitabine/Cisplatin 41.1; Doxorubicin 37.5; Topotecan 33.8; Paclitaxel 33.2; Doxorubicin30.7; Cisplatin 25.5; Gemcitabine/Carboplatin 20.7; Carboplatin 12.6; Gemcitabine <10 | Docetaxel 63.9; Paclitaxel/Carboplatin 60.3; Topotecan 57.5; Doxorubicin/Carboplatin 56.2; Docetaxel/Carboplatin 50.9; Paclitaxel 49.5; Gemcitabine/Cisplatin 27.1; Cisplatin 26.5; Doxorubicin 25.6; Carboplatin 16.8; Gemcitabine/Carboplatin <10; Gemcitabine <10 | PD |
30 | Doxorubicin | Docetaxel/Carboplatin 73.0; Gemcitabine/Cisplatin 72.7; Docetaxel 68.2; Cisplatin 63.9; Doxorubicin/Carboplatin 61.6; Doxorubicin 51.4; Paclitaxel/Carboplatin 35.3; Gemcitabine/Carboplatin 26.4; Paclitaxel 25.7; Carboplatin <10; Gemcitabine <10; Topotecan <10 | Doxorubicin/Carboplatin 57.3; Docetaxel/Carboplatin 47.4; Cisplatin 42.6; Doxorubicin 41.3; Gemcitabine/Cisplatin 38.1; Paclitaxel/Carboplatin 32.0; Topotecan 31.3; Docetaxel 22.2; Gemcitabine/Carboplatin 11.4; Paclitaxel 10.3; Carboplatin <10; Gemcitabine <10 | PD |
31 | Gemcitabine/Cisplatin | Doxorubicin/Carboplatin 54.2; Docetaxel/Carboplatin 52.2; Paclitaxel/Carboplatin 48.8; Docetaxel 41.0; Gemcitabine/Cisplatin 35.3; Paclitaxel 33.5; Cisplatin 30.6; Gemcitabine/Carboplatin 29.9; Topotecan 22.5; Carboplatin 21.4; Doxorubicin <10; Gemcitabine <10 | Doxorubicin/Carboplatin 65.3; Gemcitabine/Cisplatin 47.6; Paclitaxel/Carboplatin 44.5; Docetaxel/Carboplatin 40.2; Cisplatin 35.9; Doxorubicin 26.0; Gemcitabine/Carboplatin 18.3; Paclitaxel 14.6; Docetaxel 12.6; Carboplatin <10; Gemcitabine <10 | PD |
32 | Doxorubicin | Docetaxel/Carboplatin 59.6; Docetaxel 54.9; Doxorubicin 39.8; Gemcitabine/Cisplatin 35.5; Doxorubicin/Carboplatin 32.2; Paclitaxel/Carboplatin <10; Cisplatin <10; Paclitaxel <10; Gemcitabine <10; Carboplatin <10; Gemcitabine/Carboplatin <10; Topotecan <10 | Docetaxel/Carboplatin 74.0; Paclitaxel/Carboplatin 60.4; Paclitaxel 47.4; Docetaxel 41.6; Doxorubicin/Carboplatin 41.4; Gemcitabine/Cisplatin 35.7; Cisplatin 32.9; Topotecan 32.2; Doxorubicin 29.0; Gemcitabine/Carboplatin 16.6; Carboplatin <10 | SD |
33 | Gemcitabine | Gemcitabine/Cisplatin 57.7; Docetaxel/Carboplatin 55.9; Doxorubicin/Carboplatin 53.7; Cisplatin 45.5; Paclitaxel/Carboplatin 37.0; Docetaxel 29.6; Gemcitabine/Carboplatin 27.7; Doxorubicin 27.7; Carboplatin 17.1; Topotecan 13.1; Paclitaxel 11.2; Gemcitabine <10 | Gemcitabine/Cisplatin 61.0; Doxorubicin/Carboplatin 55.2; Cisplatin 54.0; Docetaxel/Carboplatin 51.6; Gemcitabine 49.9; Doxorubicin 49.5; Gemcitabine/Carboplatin 39.9; Carboplatin 38.0; Docetaxel 32.3; Paclitaxel 31.6; Paclitaxel/Carboplatin 30.8; Topotecan 17.8 | SD |
34 | Gemcitabine/Carboplatin | Paclitaxel/Carboplatin 48.6; Carboplatin 42.7; Paclitaxel 22.5; Docetaxel/Carboplatin 20.3; Doxorubicin 18.6; Cisplatin 16.7; Gemcitabine 13.8; Docetaxel <10; Gemcitabine/Carboplatin <10; Doxorubicin/Carboplatin <10; Gemcitabine/Cisplatin <10; Topotecan <10 | Doxorubicin 35.5; Gemcitabine/Cisplatin 35.2; Paclitaxel 29.0; Paclitaxel/Carboplatin 21.9; Cisplatin 20.9; Docetaxel/Carboplatin 20.8; Carboplatin 17.7; Docetaxel 12.8; Gemcitabine 10.2; Gemcitabine/Carboplatin <10 | SD |
35 | Doxorubicin/Carboplatin | Doxorubicin/Carboplatin 72.8; Doxorubicin 57.8; Paclitaxel/Carboplatin 53.8; Gemcitabine/Cisplatin 52.3; Docetaxel 45.6; Topotecan 45.5; Cisplatin 44.7; Paclitaxel/Carboplatin 44.4; Paclitaxel 34.6; Docetaxel/Carboplatin 33.4; Gemcitabine/Carboplatin 27.8; Carboplatin <10; Gemcitabine <10 | Doxorubicin/Carboplatin 66.8; Doxorubicin 52.4; Paclitaxel/Carboplatin 48.9; Gemcitabine/Cisplatin 42.1; Docetaxel 36.4; Topotecan 30.0; Cisplatin 29.5; Paclitaxel/Carboplatin 25.6; Paclitaxel 21.0; Docetaxel/Carboplatin 15.3; Gemcitabine/Carboplatin 12.4; Carboplatin <10; Gemcitabine <10 | SD |
36 | Docetaxel | Docetaxel/Carboplatin 74.9; Doxorubicin 65.0; Paclitaxel/Carboplatin 65.0; Doxorubicin 64.9; Paclitaxel/Carboplatin 64.8; Carboplatin 61.9; Doxorubicin/Carboplatin 60.7; Gemcitabine/Cisplatin 59.7; Docetaxel 56.7; Gemcitabine 56.5; Paclitaxel 54.4; Cisplatin 50.7; Gemcitabine/Carboplatin 39.7; Topotecan 37.3 | Docetaxel/Carboplatin 70.3; Doxorubicin 65.0; Paclitaxel/Carboplatin 60.3; Doxorubicin 59.6; Paclitaxel/Carboplatin 58.4; Carboplatin 57.5; Doxorubicin/Carboplatin 52.3; Gemcitabine/Cisplatin 51.6; Docetaxel 51.3; Gemcitabine 33.4; Paclitaxel 32.1; Cisplatin 30.0; Gemcitabine/Carboplatin 19.7; Topotecan 17.3 | SD |
37 | Paclitaxel/Carboplatin | Gemcitabine/Cisplatin 78.8; Doxorubicin 78.7; Doxorubicin/Carboplatin 75.9; Docetaxel /Carboplatin 75.1; Cisplatin 63.5; Gemcitabine/Carboplatin 42.6; Gemcitabine 40.4; Paclitaxel/Carboplatin 33.6; Docetaxel 33.2; Carboplatin 32.6; Paclitaxel 27.4; Topotecan <10 | Doxorubicin/Carboplatin 58.5; Paclitaxel/Carboplatin 53.8; Docetaxel/Carboplatin 48.2; Gemcitabine/Cisplatin 46.9; Cisplatin 44.5; Docetaxel 35.4; Paclitaxel 33.8; Gemcitabine/Carboplatin 32.3; Doxorubicin 31.9; Topotecan 26.3; Carboplatin 22.1; Gemcitabine <10 | SD |
38 | Doxorubicin/Carboplatin | Doxorubicin/Carboplatin 70.8; Docetaxel/Carboplatin 64.4; Docetaxel 61.3; Gemcitabine/Cisplatin 58.0; Paclitaxel/Carboplatin 56.1; Paclitaxel 50.8; Cisplatin 48.2; Doxorubicin 47.9; Paclitaxel/Carboplatin 40.5; Gemcitabine/Carboplatin 39.3; Topotecan 39.1; Carboplatin 29.2; Gemcitabine 23.0 | Doxorubicin/Carboplatin 70.8; Docetaxel/Carboplatin 54.9; Docetaxel 49.1; Paclitaxel/Carboplatin 45.0; Doxorubicin 37.6; Gemcitabine/Cisplatin 28.4; Topotecan 27.0; Paclitaxel 23.2; Cisplatin 20.5; Carboplatin 10.4; Gemcitabine <10; Gemcitabine/Carboplatin <10 | SD |
39 | Doxorubicin/Carboplatin | Docetaxel/Carboplatin 63.4; Doxorubicin 59.9; Paclitaxel/Carboplatin 58.7; Carboplatin 55.2; Doxorubicin/Carboplatin 54.5; Gemcitabine/Cisplatin 45.9; Docetaxel 40.3; Gemcitabine 38.4; Paclitaxel 27.4; Cisplatin 25.7; Gemcitabine/Carboplatin 19.7; Topotecan 17.3 | Docetaxel/Carboplatin 62.3; Doxorubicin 56.0; Paclitaxel/Carboplatin 52.3; Paclitaxel/Carboplatin 58.4; Carboplatin 57.5; Doxorubicin/Carboplatin 52.1; Gemcitabine/Cisplatin 51.6; Docetaxel 51.2; Gemcitabine 33.4; Paclitaxel 32.1; Cisplatin 30.0; Gemcitabine/Carboplatin 19.9; Topotecan 17.3 | SD |
40 | Paclitaxel/Carboplatin | Paclitaxel/Carboplatin 62.3; Doxorubicin/Carboplatin 61.2; Gemcitabine/Cisplatin 60.6; Docetaxel 55.0; Paclitaxel 54.8; Cisplatin 53.7; Doxorubicin 50.1; Carboplatin 30.1; Topotecan 23.4; Gemcitabine 20.8; Gemcitabine/Carboplatin <10 | Doxorubicin/Carboplatin 50.3; Gemcitabine/Cisplatin 38.9; Docetaxel 37.1; Paclitaxel 35.4; Cisplatin 38.1; Paclitaxel/Carboplatin 30.0; Doxorubicin 27.3; Carboplatin 22.2; Topotecan <10; Gemcitabine <10; Gemcitabine/Carboplatin <10 | PR |
41 | Doxorubicin | Doxorubicin/Carboplatin 91.7; Doxorubicin 88.2; Gemcitabine/Cisplatin 80.9; Cisplatin 70.3; Paclitaxel/Carboplatin 61.4; Gemcitabine/Carboplatin 54.8; Docetaxel/Carboplatin 51.6; Docetaxel 46.1; Paclitaxel 43.6; Paclitaxel/Carboplatin 33.6; Topotecan 31.4; Gemcitabine 20.0; Carboplatin <10 | Doxorubicin/Carboplatin 96.1; Docetaxel/Carboplatin 79.5; Paclitaxel/Carboplatin 79.1; Doxorubicin 71.5; Paclitaxel 64.3; Docetaxel 63.1; Gemcitabine/Cisplatin 61.7; Paclitaxel/Carboplatin 48.5; Topotecan 38.7; Cisplatin 34.4; Carboplatin 20.0; Gemcitabine 11.9; Carboplatin <10; Gemcitabine/Carboplatin <10 | CR |
