Table 7 ChemoID-guided arm Predicted Drugs (treatment was guided by the test results)
Patient no. | Treatment received | ChemoID cytotoxic profile for Bulk of Tumor (high cell kill: > 50%; low cell kill: <50%) | ChemoID cytotoxic profile for CSCs (high cell kill: > 50%; low cell kill: <50%) | Response as per RECIST 1.1 criteria |
|---|---|---|---|---|
1 | Gemcitabine/Carboplatin | Gemcitabine/Cisplatin 33.3; Doxorubicin/Carboplatin 32.4; Cisplatin 30.9; Doxorubicin29.1; Gemcitabine 27.9; Carboplatin 25.7; Gemcitabine/Carboplatin 23.7; Paclitaxel/Carboplatin 23.7; Paclitaxel 15.4; Docetaxel/Carboplatin 13.2; Topotecan 13.2; Docetaxel <10; Carboplatin <10 | Paclitaxel/Carboplatin 39.7; Doxorubicin/Carboplatin 33.4; Paclitaxel 32.0; Cisplatin 31.0; Docetaxel/Carboplatin 30.8; Docetaxel 29.7; Gemcitabine/Cisplatin 26.5; Topotecan 23.6; Doxorubicin 16.2; Carboplatin 10.6; Gemcitabine <10; Gemcitabine/Carboplatin <10 | PD |
2 | Paclitaxel/Carboplatin | Paclitaxel/Carboplatin 60.8; Docetaxel/Carboplatin54.0; Cisplatin 51.7; Gemcitabine/Cisplatin 49.9; Doxorubicin/Carboplatin 41.2; Paclitaxel 38.7; Docetaxel 38.2; Gemcitabine/Carboplatin 36.0; Gemcitabine 26.6; Doxorubicin 26.1; Carboplatin23.4; Topotecan 11.2 | Gemcitabine/Cisplatin 41.9; Paclitaxel/Carboplatin 35.2; Doxorubicin/Carboplatin 20.9; Docetaxel/Carboplatin 20.7; Docetaxel <10; Doxorubicin <10; Paclitaxel <10; Cisplatin Gemcitabine/Carboplatin <10; Carboplatin <10; Topotecan <10; Gemcitabine <10 | PD |
3 | Paclitaxel/Carboplatin | Gemcitabine/Cisplatin 51.0; Paclitaxel/Carboplatin 50.5; Docetaxel 42.9; Doxorubicin/Carboplatin 39.3; Paclitaxel 37.3; Cisplatin 35.7; Docetaxel/Carboplatin 34.6; Doxorubicin 29.2; Gemcitabine/Carboplatin 26.8; Topotecan 24.0; Carboplatin 11.5; Gemcitabine <10 | Doxorubicin/Carboplatin 59.6; Paclitaxel/Carboplatin 37.8; Docetaxel 32.5; Paclitaxel/Carboplatin 31.1; Gemcitabine/Cisplatin 31.1; Topotecan 28.4; Docetaxel/Carboplatin 26.5; Doxorubicin 21.5; Paclitaxel 19.9; Cisplatin 17.9; Carboplatin <10; Gemcitabine <10; Gemcitabine/Carboplatin <10 | PD |
4 | Docetaxel | Doxorubicin 48.5; Docetaxel/Carboplatin 46.5; Docetaxel 43.6; Paclitaxel/Carboplatin 43.1; Gemcitabine 41.0; Carboplatin 38.2; Cisplatin 22.8; Paclitaxel 21.4; Doxorubicin/Carboplatin 16.4; Gemcitabine/Carboplatin <10; Topotecan <10; Gemcitabine/Cisplatin <10 | Docetaxel/Carboplatin 58.4; Doxorubicin/Carboplatin 47.2; Paclitaxel/Carboplatin 46.9; Paclitaxel 37.9; Doxorubicin 35.4; Docetaxel 33.2; Carboplatin 32.8; Gemcitabine 23.9 | PD |
5 | Docetaxel/Carboplatin | Docetaxel/Carboplatin 80.8; Docetaxel 69.5; Doxorubicin/Carboplatin 37.5; Gemcitabine/Cisplatin 35.5; Cisplatin 33.8; Doxorubicin 28.2; Gemcitabine/Carboplatin 24.9; Gemcitabine 20.7; Paclitaxel/Carboplatin 19.7; Carboplatin <10; Topotecan <10; Paclitaxel <10 | Docetaxel/Carboplatin 32.7; Doxorubicin/Carboplatin 29.3; Docetaxel 28.5; Gemcitabine/Cisplatin 22.6; Cisplatin 23.8; Doxorubicin 15.3; Gemcitabine/Carboplatin 12.0; Doxorubicin 10.9; Gemcitabine <10; Paclitaxel/Carboplatin <10; Carboplatin <10; Topotecan <10; Paclitaxel <10 | PD |
6 | Doxorubicin/Carboplatin | Doxorubicin/Carboplatin 95.4; Doxorubicin 89.3; Gemcitabine/Cisplatin 88.9; Paclitaxel 74.9; Paclitaxel/Carboplatin 73.8; Docetaxel/Carboplatin 72.8; Docetaxel 70.6; Cisplatin 69.5; Gemcitabine/Carboplatin 58.9; Topotecan 58.5; Carboplatin 29.4; Gemcitabine 20.8 | Doxorubicin/Carboplatin 75.8; Paclitaxel/Carboplatin 74.3; Gemcitabine/Cisplatin 73.4; Docetaxel/Carboplatin 67.4; Paclitaxel 61.9; Doxorubicin 55.4; Cisplatin 48.6; Gemcitabine/Carboplatin 26.0; Docetaxel 24.9; Gemcitabine 13.8; Carboplatin <10; Topotecan <10 | PD |
7 | Doxorubicin | Doxorubicin/Carboplatin 85.1; Gemcitabine/Cisplatin 71.1; Doxorubicin 70.4; Cisplatin 61.3; Docetaxel/Carboplatin 60.6; Paclitaxel/Carboplatin 56.1; Docetaxel 46.0; Topotecan 42.3; Paclitaxel 31.3; Carboplatin 10.1; Gemcitabine/Carboplatin <10; Gemcitabine <10 | Docetaxel/Carboplatin 60.5; Paclitaxel/Carboplatin 56.0; Carboplatin 47.6; Gemcitabine 40.0; Doxorubicin/Carboplatin 39.1; Gemcitabine/Cisplatin 38.6; Docetaxel 37.2; Doxorubicin 22.5; Cisplatin 17.2; Paclitaxel 15.3; Gemcitabine/Carboplatin 12.9; Topotecan <10 | PD |
8 | Docetaxel | Docetaxel/Carboplatin 92.2; Docetaxel 84.1; Paclitaxel/Carboplatin 76.8; Paclitaxel 61.3; Doxorubicin 53.6; Cisplatin 52.0; Topotecan 50.9; Doxorubicin/Carboplatin 47.8; Gemcitabine/Cisplatin 47.0; Carboplatin 29.5; Gemcitabine/Carboplatin 25.2; Gemcitabine 11.5 | Topotecan 39.3; Paclitaxel/Carboplatin 38.9; Docetaxel/Carboplatin 38.7; Docetaxel 33.5; Paclitaxel 22.6; Doxorubicin/Carboplatin 16.0; Cisplatin 11.0; Gemcitabine/Cisplatin <10; Doxorubicin <10; Carboplatin <10; Gemcitabine <10; Gemcitabine/Carboplatin <10 | SD |
9 | Gemcitabine/Cisplatin | Doxorubicin/Carboplatin 77.7; Gemcitabine/Cisplatin 73.4; Docetaxel/Carboplatin 73.3; Doxorubicin 69.8; Cisplatin 68.9; Paclitaxel/Carboplatin 63.1; Docetaxel 58.9; Gemcitabine/Carboplatin 57.5; Topotecan 55.0; Paclitaxel 33.3; Carboplatin 11.6; Gemcitabine 10.8 | Doxorubicin/Carboplatin 79.7; Docetaxel/Carboplatin 77.7; Docetaxel 72.1; Cisplatin 67.1; Doxorubicin 65.2; Paclitaxel/Carboplatin 65.1; Gemcitabine 50.3; Carboplatin 49.1; Paclitaxel 48.6; Topotecan 45.5; Gemcitabine/Carboplatin 20.3; Gemcitabine/Cisplatin 13.4 | SD |
10 | Docetaxel/Carboplatin | Docetaxel/Carboplatin 63.9; Gemcitabine/Cisplatin 48.3; Paclitaxel/Carboplatin 44.7; Paclitaxel 29.3; Docetaxel 25.0; Doxorubicin/Carboplatin 16.0; Cisplatin 12.3; Gemcitabine 11.9; Gemcitabine/Carboplatin 11.8; Doxorubicin <10; Topotecan <10; Carboplatin <10 | Docetaxel/Carboplatin 72.3; Gemcitabine/Cisplatin 70.7; Paclitaxel/Carboplatin 60.8; Carboplatin 56.8; Cisplatin 54.9; Gemcitabine/Carboplatin 54.6; Doxorubicin 52.7; Gemcitabine 52.4; Doxorubicin/Carboplatin 48.1; Docetaxel 45.1; Paclitaxel 43.9; Topotecan 42.1 | SD |
11 | Docetaxel/Carboplatin | Docetaxel/Carboplatin 63.8 Doxorubicin 61.8; Doxorubicin/Carboplatin 59.9; Docetaxel 55.9; Gemcitabine/Cisplatin 52.3; Paclitaxel/Carboplatin 51.2; Topotecan 47.6; Paclitaxel 38.1; Cisplatin 26.5; Gemcitabine/Carboplatin 16.2; Gemcitabine <10; Carboplatin <10 | Docetaxel/Carboplatin 84.8; Doxorubicin/Carboplatin 75.1; Gemcitabine/Cisplatin 67.5; Docetaxel 66.3; Cisplatin 62.3; Paclitaxel/Carboplatin 55.1; Paclitaxel 39.1; Doxorubicin 33.5; Gemcitabine/Carboplatin 30.1; Carboplatin 23.8; Gemcitabine <10; Topotecan <10 | SD |
12 | Paclitaxel/Carboplatin | Doxorubicin/Carboplatin 46.9; Paclitaxel/Carboplatin 42.0; Docetaxel 36.6; Docetaxel/Carboplatin 33.9; Gemcitabine/Cisplatin 31.0; Topotecan 17.9; Paclitaxel <10; Doxorubicin <10; Gemcitabine/Carboplatin <10; Cisplatin <10; Gemcitabine <10; Carboplatin <10 | Paclitaxel/Carboplatin 54.5; Doxorubicin/Carboplatin 48.3; Docetaxel 47.1; Docetaxel/Carboplatin 40.9; Paclitaxel/Carboplatin 33.2; Topotecan 26.5; Paclitaxel 25.3; Doxorubicin 18.8; Gemcitabine/Cisplatin 18.0; Cisplatin <10; Gemcitabine/Carboplatin <10; Gemcitabine <10; Carboplatin <10 | SD |
13 | Doxorubicin/Carboplatin | Doxorubicin/Carboplatin 86.0; Paclitaxel/Carboplatin 74.5; Doxorubicin 70.5; Docetaxel 703; Docetaxel/Carboplatin 62.2; Gemcitabine/Cisplatin 52.8; Cisplatin 40.1; Paclitaxel 28.4; Gemcitabine/Carboplatin 23.1; Topotecan 21.1; Carboplatin <10; Gemcitabine <10 | Docetaxel/Carboplatin 81.1; Doxorubicin/Carboplatin 77.3; Doxorubicin 68.3; Docetaxel 50.5; Gemcitabine/Cisplatin 50.3; Paclitaxel/Carboplatin 43.6; Cisplatin 38.1; Paclitaxel 37.4; Topotecan 36.7; Gemcitabine/Carboplatin 10.8; Gemcitabine <10; Carboplatin <10 | SD |
14 | Doxorubicin | Doxorubicin 51.8; Carboplatin 47.8; Paclitaxel 47.2; Docetaxel 43.2; Paclitaxel/Carboplatin 40.5 | Doxorubicin 49.5; Carboplatin 48.7; Paclitaxel 44.5; Docetaxel 42.1; Paclitaxel/Carboplatin 36.6 | SD |
15 | Paclitaxel/Carboplatin | Doxorubicin/Carboplatin 64.9; Paclitaxel/Carboplatin 50.8; Docetaxel/Carboplatin 45.8 Gemcitabine/Cisplatin43.6; Docetaxel40.6; Cisplatin 37.2; Topotecan 32.8; Paclitaxel 31.7; Paclitaxel/Carboplatin 31.3; Gemcitabine/Carboplatin 28.8; Doxorubicin 27.4; Gemcitabine 22.2; Carboplatin 15.4 | Paclitaxel/Carboplatin 60.2; Docetaxel/Carboplatin 51.3; Doxorubicin/Carboplatin 50.9; Gemcitabine/Cisplatin 39.7; Docetaxel 30.2; Cisplatin 28.7; Topotecan 28.6; Paclitaxel 25.2; Paclitaxel/Carboplatin 22.0; Gemcitabine/Carboplatin 19.4; Doxorubicin 11.7; Gemcitabine <10; Carboplatin <10 | SD |
16 | Paclitaxel/Carboplatin | Doxorubicin/Carboplatin 56.3; Docetaxel 47.8; Paclitaxel/Carboplatin 46.9; Topotecan 43.8; Paclitaxel 36.0; Docetaxel/Carboplatin 34.4; Gemcitabine/Cisplatin 28.9; Cisplatin 27.8; Doxorubicin 26.7; Gemcitabine/Carboplatin 15.6; Carboplatin12.2; Gemcitabine <10 | Paclitaxel/Carboplatin 72.7; Doxorubicin 71.2; Cisplatin 66.1; Doxorubicin/Carboplatin 65.6; Paclitaxel 64.5; Carboplatin 63.4; Docetaxel 63.4; Gemcitabine 59.9; Docetaxel/Carboplatin 65.5; Topotecan 44.1 | SD |
17 | Gemcitabine | Docetaxel/Carboplatin 48.1; Gemcitabine 42.8; Doxorubicin 41.9; Paclitaxel/Carboplatin 37.4; Paclitaxel 28.5; Gemcitabine/Cisplatin 23.5; Carboplatin 23.4; Docetaxel 20.3; Cisplatin 20.3; Doxorubicin/Carboplatin 18.2; Gemcitabine/Carboplatin 16.5; Topotecan <10 | Gemcitabine 43.0; Paclitaxel 41.3; Cisplatin 40.9; Doxorubicin 36.8; Carboplatin 36.5; Doxorubicin/Carboplatin 31.3; Docetaxel/Carboplatin 29.2; Gemcitabine/Cisplatin 29.0; Paclitaxel/Carboplatin 28.3; Gemcitabine/Carboplatin 22.3; Docetaxel 14.0; Topotecan <10 | SD |
18 | Gemcitabine | Gemcitabine 50.5; Gemcitabine/Cisplatin 37.9; Cisplatin 32.7; Gemcitabine/Carboplatin 27.8; Doxorubicin/Carboplatin 23.7; Doxorubicin 18.2; Docetaxel <10; Carboplatin <10; Paclitaxel/Carboplatin <10; Topotecan <10; Paclitaxel <10; Docetaxel/Carboplatin <10 | Gemcitabine 41.3; Cisplatin 33.2; Docetaxel/Carboplatin 30.7; Paclitaxel/Carboplatin 30.6; Docetaxel 28.0; Gemcitabine/Cisplatin 21.0; Paclitaxel 17.3; Doxorubicin 10.5; Topotecan <10; Doxorubicin/Carboplatin <10; Gemcitabine/Carboplatin <10; Carboplatin <10 | SD |
19 | Docetaxel/Carboplatin | Docetaxel/Carboplatin 71.8; Paclitaxel/Carboplatin 55.8; Gemcitabine 42.5; Paclitaxel 34.7; Doxorubicin/Carboplatin 34.0; Gemcitabine/Carboplatin 28.1; Cisplatin 29.2; Gemcitabine/Cisplatin 28.1; Carboplatin 22.0; Docetaxel <10; Doxorubicin <10; Topotecan <10 | Docetaxel/Carboplatin 69.4; Paclitaxel/Carboplatin 51.8; Gemcitabine 40.2; Paclitaxel 36.7; Doxorubicin/Carboplatin 30.0; Gemcitabine/Carboplatin 29.6; Cisplatin 29.0; Gemcitabine/Cisplatin 24.1; Carboplatin 12.5; Docetaxel <10; Doxorubicin <10; Topotecan <10 | SD |
20 | Paclitaxel/Carboplatin | Paclitaxel/Carboplatin 100; Cisplatin 61.1; Paclitaxel 57.2; Doxorubicin/Carboplatin 49.8; Carboplatin 47.6; Doxorubicin 47.2 | Paclitaxel/Carboplatin 72.6; Cisplatin 52.4; Paclitaxel 44.5; Doxorubicin/Carboplatin 42.1; Carboplatin 36.6; Doxorubicin 30.1 | SD |
21 | Doxorubicin/Carboplatin | Doxorubicin/Carboplatin 85.6; Gemcitabine/Cisplatin 83.6; Doxorubicin 79.8; Docetaxel/Carboplatin 72.0; Cisplatin 70.0; Gemcitabine/Carboplatin 61.0; Paclitaxel/Carboplatin 54.1; Paclitaxel 49.0; Docetaxel 38.2; Gemcitabine 36.7; Topotecan 12.2; Carboplatin 10.9 | Docetaxel/Carboplatin 86.9; Doxorubicin/Carboplatin 82.1; Docetaxel 76.2; Paclitaxel/Carboplatin 75.7; Paclitaxel 57.7; Doxorubicin 56.9; Topotecan 53.4; Gemcitabine/Cisplatin 34.6; Cisplatin 32.2; Gemcitabine 17.7; Carboplatin <10; Gemcitabine/Carboplatin <10 | PR |
22 | Paclitaxel | Paclitaxel 68.9; Paclitaxel/Carboplatin 64.4; Doxorubicin 55.4; Gemcitabine/Cisplatin 52.6; Docetaxel/Carboplatin 46.1; Doxorubicin/Carboplatin 43.9; Paclitaxel/Carboplatin 39.9; Cisplatin 38.3; Gemcitabine/Carboplatin 38.3; Paclitaxel 34.9; Docetaxel 29.1; Topotecan <10; Carboplatin <10; Gemcitabine <10 | Paclitaxel/Carboplatin 78.8; Doxorubicin/Carboplatin 68.3; Doxorubicin 46.1; Gemcitabine/Cisplatin 45.0; Cisplatin 38.3; Docetaxel/Carboplatin 25.4; Paclitaxel/Carboplatin 23.6; Docetaxel Carboplatin 11.0; Paclitaxel <10; Gemcitabine/Carboplatin <10; Gemcitabine <10 | PR |
23 | Doxorubicin | Doxorubicin 35.7; Docetaxel/Carboplatin 30.4; Paclitaxel 23.0; Doxorubicin/Carboplatin 22.6; Gemcitabine 22.2; Paclitaxel/Carboplatin 17.7; Carboplatin 13.4; Cisplatin 11.5; Docetaxel <10; Gemcitabine/Cisplatin <10; Gemcitabine/Carboplatin <10; Topotecan <10 | Docetaxel/Carboplatin 54.7; Doxorubicin 52.5; Doxorubicin/Carboplatin 46.4; Gemcitabine 44.7; Doxorubicin 42.9; Gemcitabine/Cisplatin 41.7; Paclitaxel 41.6; Carboplatin 41.3; Paclitaxel/Carboplatin 38.9; Cisplatin 35.0; Docetaxel 20.1; Gemcitabine/Carboplatin 19.4; Topotecan <10 | PR |
24 | Paclitaxel/Carboplatin | Doxorubicin/Carboplatin 62.5; Docetaxel 54.8; Paclitaxel/Carboplatin 51.8; Gemcitabine/Cisplatin 50.3; Topotecan 45.6; Cisplatin 44.1; Gemcitabine/Carboplatin 36.8; Docetaxel/Carboplatin 36.5; Paclitaxel/Carboplatin 34.6; Paclitaxel 29.9; Carboplatin 21.7; Gemcitabine 18.1; Doxorubicin 13.6 | Doxorubicin 40.6; Paclitaxel/Carboplatin 40.3; Docetaxel/Carboplatin 39.7; Doxorubicin/Carboplatin 38.6; Paclitaxel/Carboplatin 38.6; Gemcitabine/Cisplatin 28.9; Docetaxel 28.5; Topotecan 22.0; Paclitaxel 20.6; Gemcitabine/Carboplatin 15.4 | PR |
25 | Doxorubicin/Carboplatin | Doxorubicin/Carboplatin 79.9; Doxorubicin 75.4; Docetaxel/Carboplatin 68.7; Docetaxel 64.4; Gemcitabine/Cisplatin 61.0; Paclitaxel/Carboplatin 59.2; Topotecan 50.5; Cisplatin 50.5; Paclitaxel 31.1; Gemcitabine/Carboplatin 26.8; Carboplatin 11.5; Gemcitabine<10 | Docetaxel/Carboplatin 84.9; Docetaxel 62.9; Doxorubicin/Carboplatin 38.5; Gemcitabine/Cisplatin 35.6; Cisplatin 31.2; Paclitaxel/Carboplatin 30.0; Doxorubicin <10; Paclitaxel <10; Gemcitabine/Carboplatin <10; Carboplatin <10; Topotecan <10; Gemcitabine <10 | PR |
26 | Docetaxel/Carboplatin | Docetaxel/Carboplatin 40.5; Gemcitabine/Cisplatin 28.5; Cisplatin 25.6; Docetaxel 18.1; Doxorubicin 13.4; Paclitaxel 12.4; Carboplatin 11.6; Gemcitabine/Carboplatin <10; Gemcitabine <10; Topotecan <10 | Docetaxel/Carboplatin 55.5; Gemcitabine/Cisplatin 22.5; Cisplatin 18.6; Docetaxel 18.0; Doxorubicin 11.9; Paclitaxel 10.4; Carboplatin 10.2; Gemcitabine/Carboplatin <10; Gemcitabine <10; Topotecan <10 | PR |
27 | Doxorubicin/Carboplatin | Doxorubicin/Carboplatin 55.2; Paclitaxel/Carboplatin 52.6; Topotecan 37.8; Docetaxel 37.0; Docetaxel/Carboplatin 32.7; Paclitaxel 29.4; Cisplatin 23.8; Gemcitabine/Cisplatin 19.7; Doxorubicin 15.6; Gemcitabine/Carboplatin 14.4; Carboplatin 13.1; Gemcitabine <10 | Doxorubicin/Carboplatin 73.8; Gemcitabine/Cisplatin 67.5; Cisplatin 64.0; Doxorubicin 55.7; Paclitaxel/Carboplatin 44.7; Paclitaxel 43.5; Carboplatin 37.1; Gemcitabine 34.9; Docetaxel/Carboplatin 31.2; Topotecan 22.4; Docetaxel 21.0 | PR |
28 | Doxorubicin/Carboplatin | Doxorubicin/Carboplatin 49.1; Doxorubicin 44.0; Gemcitabine/Cisplatin 40.5; Gemcitabine 35.7; Cisplatin 26.9; Carboplatin 23.3; Topotecan 21.1; Paclitaxel/Carboplatin 15.6; Docetaxel/Carboplatin 14.7; Paclitaxel 11.6; Docetaxel <10; Gemcitabine/Carboplatin <10 | Docetaxel/Carboplatin 37.5; Doxorubicin/Carboplatin 34.1; Gemcitabine/Cisplatin 33.9; Paclitaxel/Carboplatin 32.4; Paclitaxel 28.9; Doxorubicin 28.2; Carboplatin 25.8; Gemcitabine 21.5; Cisplatin 20.9; Docetaxel 18.8; Gemcitabine/Carboplatin 12.5; Topotecan <10 | PR |
29 | Docetaxel | Paclitaxel/Carboplatin 76.6; Docetaxel 73.7; Docetaxel/Carboplatin 71.3; Paclitaxel/Carboplatin 51.4; Doxorubicin/Carboplatin 50.1; Topotecan 44.4; Paclitaxel 41.6; Cisplatin 27.9; Gemcitabine/Cisplatin 25.0; Gemcitabine/Carboplatin 17.6; Doxorubicin <10; Carboplatin <10; Gemcitabine <10 | Docetaxel 51.2; Topotecan 45.5; Docetaxel/Carboplatin 46.2; Paclitaxel/Carboplatin 41.1; Doxorubicin/Carboplatin 37.2; Gemcitabine/Cisplatin 28.5; Paclitaxel 24.2; Carboplatin 14.5; Gemcitabine/Carboplatin <10; Doxorubicin <10; Gemcitabine <10 | PR |
30 | Docetaxel/Carboplatin | Docetaxel/Carboplatin 83.5; Docetaxel 83.2; Doxorubicin/Carboplatin 75.1; Paclitaxel/Carboplatin 71.2; Gemcitabine/Cisplatin 46.2; Doxorubicin 43.0; Cisplatin 42.5; Topotecan 40.7; Gemcitabine/Carboplatin 27.1; Paclitaxel 26.1; Carboplatin <10; Gemcitabine <10 | Docetaxel/Carboplatin 79.4; Paclitaxel/Carboplatin 65.2; Docetaxel 63.6; Doxorubicin/Carboplatin 59.9; Doxorubicin 51.2; Paclitaxel 50.2; Carboplatin 41.4 | PR |
31 | Doxorubicin/Carboplatin | Doxorubicin/Carboplatin 69.6; Paclitaxel/Carboplatin 64.9; Docetaxel 60.7; Gemcitabine/Cisplatin 48.6; Cisplatin 47.2; Docetaxel/Carboplatin 44.1; Topotecan 40.6; Paclitaxel 37.6; Doxorubicin 36.1; Gemcitabine/Carboplatin 13.4; Carboplatin <10; Gemcitabine <10 | Paclitaxel 79.9; Docetaxel 77.4; Doxorubicin 71.6; Cisplatin 67.4; Topotecan 66.3; Paclitaxel/Carboplatin 65.1; Gemcitabine/Cisplatin 64.5; Docetaxel/Carboplatin 63.9; Gemcitabine 62.8; Carboplatin 61.5; Doxorubicin/Carboplatin 59.7 | PR |
32 | Docetaxel/Carboplatin | Docetaxel/Carboplatin 51.2; Carboplatin 42.7; Cisplatin 40.3; Paclitaxel/Carboplatin 38.5; Doxorubicin 37.1; Doxorubicin/Carboplatin 33.8; Gemcitabine/Carboplatin 28.7; Docetaxel 27.7; Gemcitabine/Cisplatin 27.3; Paclitaxel 27.1; Gemcitabine 24.7; Topotecan <10 | Docetaxel/Carboplatin 50.2; Docetaxel 42.2; Paclitaxel/Carboplatin 40.1; Doxorubicin/Carboplatin 29.3; Topotecan 28.8; Cisplatin 26.5; Gemcitabine/Cisplatin 18.9; Paclitaxel 14.5; Doxorubicin <10; Gemcitabine/Carboplatin <10; Gemcitabine <10; Carboplatin <10 | PR |
33 | Gemcitabine/Cisplatin | Docetaxel/Carboplatin 75.6; Gemcitabine/Cisplatin 68.8; Docetaxel 66.2; Cisplatin 63.2; Paclitaxel/Carboplatin 56.9; Doxorubicin/Carboplatin 52.6; Doxorubicin 44.8; Paclitaxel 25.9; Carboplatin 15.2; Gemcitabine 11.1 | Gemcitabine/Cisplatin 61.3; Docetaxel/Carboplatin 52.3; Paclitaxel/Carboplatin 51.9; Docetaxel 48.7; Cisplatin 47.6; Doxorubicin/Carboplatin 42.7; Doxorubicin 41.3; Paclitaxel 35.2; Carboplatin 27.8; Gemcitabine 20.3 | PR |
34 | Docetaxel/Carboplatin | Docetaxel/Carboplatin 58.3; Docetaxel 58.1; Paclitaxel/Carboplatin 53.6; Doxorubicin/Carboplatin 52.5; Topotecan 42.4; Cisplatin 38.3; Gemcitabine/Cisplatin 35.1; Paclitaxel 32.4; Doxorubicin 30.2; Gemcitabine/Carboplatin 29.0; Gemcitabine 25.5; Carboplatin 20.7 | Docetaxel/Carboplatin 63.4; Docetaxel 45.3; Paclitaxel/Carboplatin 40.2; Doxorubicin/Carboplatin 22.6; Topotecan 23.8; Cisplatin 12.0; Gemcitabine/Cisplatin 10.9; Paclitaxel <10; Doxorubicin <10; Gemcitabine/Carboplatin <10; Gemcitabine <10; Carboplatin <10 | PR |
35 | Doxorubicin/Carboplatin | Paclitaxel/Carboplatin 68.6; Doxorubicin/Carboplatin 63.1; Docetaxel/Carboplatin 60.5; Carboplatin 52.9; Gemcitabine/Cisplatin 52.7; Paclitaxel 46.9; Docetaxel 45.6; Topotecan 45.6; Doxorubicin 40.9; Gemcitabine/Carboplatin 40.6; Carboplatin 38.9; Gemcitabine 36.8; Cisplatin <10 | Doxorubicin/Carboplatin 85.3; Paclitaxel/Carboplatin 83.3; Paclitaxel 70.4; Doxorubicin 53.5; Gemcitabine/Cisplatin 42.1; Cisplatin 35.4; Topotecan 34.5; Docetaxel/Carboplatin 30.1; Docetaxel 28.4; Carboplatin 16.4; Gemcitabine/Carboplatin 15.0; Gemcitabine <10 | PR |
36 | Docetaxel/Carboplatin | Docetaxel/Carboplatin 76.2; Docetaxel 72.2; Doxorubicin/Carboplatin 40.0; Topotecan 32.5; Paclitaxel/Carboplatin 31.9; Gemcitabine/Cisplatin 28.1; Cisplatin 22.4; Doxorubicin 21.2; Carboplatin 18.9; Paclitaxel 17.6; Gemcitabine/Carboplatin 14.1; Gemcitabine 11.4 | Docetaxel/Carboplatin 80.5; Docetaxel 76.7; Doxorubicin/Carboplatin 55.7; Paclitaxel 48.9; Doxorubicin 48.2; Paclitaxel/Carboplatin 45.9; Carboplatin 29.7; Topotecan<10 | PR |
37 | Doxorubicin/Carboplatin | Doxorubicin/Carboplatin 62.3; Paclitaxel/Carboplatin 53.8; Doxorubicin 50.6; Docetaxel 33.6; Paclitaxel 33.6; Gemcitabine/Cisplatin 31.2; Topotecan 30.1; Docetaxel/Carboplatin 29.6; Cisplatin 26.1; Gemcitabine/Carboplatin 14.3; Carboplatin 13.2; Gemcitabine 12.7 | Docetaxel/Carboplatin 70.5; Docetaxel 66.5; Doxorubicin/Carboplatin 63.5; Paclitaxel/Carboplatin 61.8; Paclitaxel 52.5; Topotecan 39.8; Gemcitabine/Cisplatin 30.5; Cisplatin 25.9; Doxorubicin 19.1; Carboplatin 11.5; Gemcitabine/Carboplatin <10; Gemcitabine <10 | PR |
38 | Doxorubicin/Carboplatin | Doxorubicin/Carboplatin 86.3; Doxorubicin 81.1; Docetaxel/Carboplatin 65.8; Paclitaxel/Carboplatin 56.6; Gemcitabine 51.2; Docetaxel 43.3; Paclitaxel 40.0; Gemcitabine/Carboplatin 32.8; Carboplatin 31.1; Cisplatin 27.8; Topotecan <10; Gemcitabine/Cisplatin <10 | Doxorubicin/Carboplatin 61.3; Doxorubicin 52.3; Docetaxel/Carboplatin 48.7; Paclitaxel/Carboplatin 47.6; Gemcitabine 42.7; Docetaxel 41.3; Paclitaxel 35.2; Gemcitabine/Carboplatin 30.0; Carboplatin 26.4; Cisplatin 20.3; Topotecan <10; Gemcitabine/Cisplatin <10 | PR |
39 | Paclitaxel/Carboplatin | Paclitaxel/Carboplatin 83.0; Gemcitabine/Cisplatin 43.3; Doxorubicin/Carboplatin 39.2; Docetaxel/Carboplatin 37.0; Paclitaxel/Carboplatin 31.1; Topotecan 29.5; Cisplatin 26.1; Docetaxel <10; Paclitaxel <10; Gemcitabine <10; Carboplatin <10; Doxorubicin <10 | Paclitaxel/Carboplatin 76.3; Gemcitabine/Cisplatin 38.9; Doxorubicin/Carboplatin 37.1; Docetaxel/Carboplatin 35.4; Paclitaxel/Carboplatin 38.1; Topotecan 32.0; Cisplatin 31.3; Docetaxel 23.0; Paclitaxel 22.2; Gemcitabine 11.4; Carboplatin <10; Doxorubicin <10 | CR |
40 | Doxorubicin/Carboplatin | Doxorubicin/Carboplatin 95.2; Doxorubicin 88.5; Gemcitabine/Cisplatin 80.9; Docetaxel/Carboplatin 78.7; Paclitaxel/Carboplatin 78.5; Docetaxel 74.2; Cisplatin 71.9; Topotecan 61.0; Paclitaxel 59.9; Gemcitabine/Carboplatin 56.2; Carboplatin 30.4; Gemcitabine 25.7 | Docetaxel/Carboplatin 95.3; Docetaxel 88.3; Doxorubicin/Carboplatin 87.3; Paclitaxel/Carboplatin 87.1; Doxorubicin 69.2; Gemcitabine/Cisplatin 62.7; Topotecan 58.2; Cisplatin 55.5; Paclitaxel 51.0; Gemcitabine/Carboplatin 30.6; Gemcitabine 15.7; Carboplatin <10 | CR |
