Fig. 2: Impact of mouse reads on genomic profiles.
From: Benchmarking mouse contamination removing protocols in patient-derived xenografts genomic profiling
a The number of somatic exonic mutations is significant higher in unsorted samples. P = 7.0e-3, paired t-test. b Mutations called in unsorted samples have lower variant allele fraction. Each dot represents the average of mutations from one sample. P = 9.2e-6, paired t-test. c SBS46 exposure is higher based on mutations detected in unsorted samples. Each dot represents the average of mutations from one sample. P = 9.4e-3, paired t-test. d Copy number profiles are highly similar between sorted and unsorted samples. Each block represents correlations of copy number profiles derived from applying different protocols to one sample. Unsorted sample is positioned first in each block.
