Fig. 4: Knockdown of SF3A3 promotes apoptosis in CRC cells. | npj Precision Oncology

Fig. 4: Knockdown of SF3A3 promotes apoptosis in CRC cells.

From: Trans-ancestry transcriptome-wide association and functional studies to uncover novel susceptibility genes and therapeutic targets for colorectal cancer

Fig. 4

A Western blot of SF3A3 protein levels in HCT116 cells with silencing of SF3A3 by siRNA. B Relative mRNA expression levels of SF3A3 in SF3A3 knockdown (SF3A3-KD) HCT116 cells. C The prominent effect of SF3A3-KD on proliferation of HCT116 cells was detected using a CCK-8 assay. D Transwell assay for evaluating the migration ability of SF3A3-KD HCT116 cells. E The prominent effect of SF3A3-KD on apoptosis of HCT116 cells was detected by flow cytometry. All experiments were repeated three times and we used the mean value to present. All *P < 0.05; **P < 0.01; ****P < 0.001, calculated by the two-tailed Student t-test.

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