Fig. 1: Patient cohort and experimental overview. | npj Precision Oncology

Fig. 1: Patient cohort and experimental overview.

From: Kinome profiling reveals pathogenic variant specific protein signalling networks in MEN2 children with Medullary Thyroid Cancer

Fig. 1

a Consort plot of experimental pipeline and samples used at each step of the study. b,c Proportion of patient samples within the kinome array shown by (b) disease type and (c) pathogenic variant group. d Calcitonin levels within patients’ blood at the time taken for the kinome analysis. e, f Calcitonin levels within patients’ blood pre-thyroidectomy. e Data grouped by pathogenic variant and coloured by Histology group. Histology group 1 (Histologically normal) orange, group 2 (C-cell hyperplasia (CCH)) pink, group 3 (Medullary thyroid cancer (MTC)) blue, group 4 (Metastatic MTC (m-MTC)) green. Cases without thyroid tissue included in this study are shown in black. f Data grouped by Histology group and coloured by pathogenic variant (C609x-C634x green, S891A orange, V804M blue, M918T purple). Those without histology data are listed under n/a. d-f Error bars represent mean with standard error of the mean (SEM). The dotted lines at 11.8 pg/ml and 4.8 pg/ml, show when calcitonin levels are considered elevated above the healthy norm for male and female children respectively. Circles depict samples from males and triangles depict samples from females.

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