Fig. 7: PGAM2 negatively correlates with PGAM2 in HCC tissues. | npj Precision Oncology

Fig. 7: PGAM2 negatively correlates with PGAM2 in HCC tissues.

From: Hepatocellular carcinoma cells downregulate PGAM2 via SIRT2-mediated deacetylation modification to enhance aerobic glycolysis

Fig. 7

A Statistical analysis of relative PGAM2 expression in paired samples from HCC patients (n = 21). B Correlation analysis of PGAM2 and SIRT2 in HCC tissues (n = 21). C Protein levels of PGAM2 and SIRT2 in HCC tissues compared with adjacent normal liver tissues based on CPTAC database. D SIRT2 and LDHA levels in HCC tissues from different clinical stages. E, F Kaplan–Meier curves of overall survival and recurrence free survival according to SIRT2 or LDHA levels in HCC tumors based on TCGA database. G Schematic model of the role of SIRT2-mediated deacetylation of PGAM2 in promoting HCC progression through activating STAT3/LDHA axis. N normal liver tissue, T tumor tissue, *p < 0.05, ***p < 0.001, ns no significance.

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